KIF3A Antibody - #DF8266
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF8266, RRID:AB_2841555.
折りたたみ／展開
KIF 3; KIF 3A; KIF3; Kif3a; KIF3A_HUMAN; Kifl; Kinesin family member 3A; Kinesin family protein 3; Kinesin family protein 3A; Kinesin like protein KIF 3A; Kinesin like protein KIF3A; Kinesin-like protein KIF3A; Kns3; Microtubule plus end directed kinesin motor 3A; Microtubule plus end-directed kinesin motor 3A;
免疫原
- Q9Y496 KIF3A_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPINKSEKPESCDNVKVVVRCRPLNEREKSMCYKQAVSVDEMRGTITVHKTDSSNEPPKTFTFDTVFGPESKQLDVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAIPELRGIIPNSFAHIFGHIAKAEGDTRFLVRVSYLEIYNEEVRDLLGKDQTQRLEVKERPDVGVYIKDLSAYVVNNADDMDRIMTLGHKNRSVGATNMNEHSSRSHAIFTITIECSEKGIDGNMHVRMGKLHLVDLAGSERQAKTGATGQRLKEATKINLSLSTLGNVISALVDGKSTHVPYRNSKLTRLLQDSLGGNSKTMMCANIGPADYNYDETISTLRYANRAKNIKNKARINEDPKDALLRQFQKEIEELKKKLEEGEEISGSDISGSEEDDDEEGEVGEDGEKRKKRRGKKKVSPDKMIEMQAKIDEERKALETKLDMEEEERNKARAELEKREKDLLKAQQEHQSLLEKLSALEKKVIVGGVDLLAKAEEQEKLLEESNMELEERRKRAEQLRRELEEKEQERLDIEEKYTSLQEEAQGKTKKLKKVWTMLMAAKSEMADLQQEHQREIEGLLENIRQLSRELRLQMLIIDNFIPRDYQEMIENYVHWNEDIGEWQLKCVAYTGNNMRKQTPVPDKKEKDPFEVDLSHVYLAYTEESLRQSLMKLERPRTSKGKARPKTGRRKRSAKPETVIDSLLQ
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9Y496 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T45 | Phosphorylation | Uniprot | |
| T47 | Phosphorylation | Uniprot | |
| T51 | Phosphorylation | Uniprot | |
| K163 | Ubiquitination | Uniprot | |
| S218 | Phosphorylation | Uniprot | |
| T316 | Phosphorylation | Uniprot | |
| Y327 | Phosphorylation | Uniprot | |
| Y329 | Phosphorylation | Uniprot | |
| Y338 | Phosphorylation | Uniprot | |
| K346 | Acetylation | Uniprot | |
| K348 | Acetylation | Uniprot | |
| K356 | Acetylation | Uniprot | |
| K356 | Ubiquitination | Uniprot | |
| K365 | Acetylation | Uniprot | |
| S381 | Phosphorylation | Uniprot | |
| S383 | Phosphorylation | Uniprot | |
| S386 | Phosphorylation | Uniprot | |
| S388 | Phosphorylation | Uniprot | |
| S415 | Phosphorylation | Uniprot | |
| K471 | Ubiquitination | Uniprot | |
| K477 | Acetylation | Uniprot | |
| K478 | Acetylation | Uniprot | |
| K478 | Ubiquitination | Uniprot | |
| K495 | Acetylation | Uniprot | |
| K531 | Ubiquitination | Uniprot | |
| K542 | Ubiquitination | Uniprot | |
| Y624 | Phosphorylation | Uniprot | |
| T633 | Phosphorylation | Uniprot | |
| K666 | Ubiquitination | Uniprot | |
| S687 | Phosphorylation | Q9UQM7 (CAMK2A) | Uniprot |
| K689 | Ubiquitination | Uniprot | |
| T692 | Phosphorylation | Uniprot |
研究背景
Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation. Plays a role in centriole cohesion and subdistal appendage organization and function. Regulates the formation of the subdistal appendage via recruitment of DCTN1 to the centriole. Also required for ciliary basal feet formation and microtubule anchoring to mother centriole.
Cytoplasm>Cytoskeleton. Cell projection>Cilium. Cytoplasm>Cytoskeleton>Microtubule organizing center>Centrosome>Centriole.
Note: Localizes to the subdistal appendage region of the centriole.
Heterodimer of KIF3A and KIF3B (By similarity). Interacts with PIFO. Interacts with CLN3. Interacts with DCTN1 (By similarity).
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.
研究領域
· Environmental Information Processing > Signal transduction > Hedgehog signaling pathway. (View pathway)
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