TPO Antibody - #DF8279
(2)
(1)
| 製品: | TPO Antibody |
| カタログ: | DF8279 |
| タンパク質の説明: | Rabbit polyclonal antibody to TPO |
| アプリケーション: | WB |
| 反応性: | Human |
| 予測: | Pig, Horse, Dog |
| 分子量: | 102 kDa; 103kD(Calculated). |
| ユニプロット: | P07202 |
| RRID: | AB_2841567 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF8279, RRID:AB_2841567.
折りたたみ／展開
MSA; PERT_HUMAN; TDH2A; Thyroid microsomal antigen; Thyroid peroxidase; Thyroperoxidase; TPO; TPX;
免疫原
- P07202 PERT_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MRALAVLSVTLVMACTEAFFPFISRGKELLWGKPEESRVSSVLEESKRLVDTAMYATMQRNLKKRGILSPAQLLSFSKLPEPTSGVIARAAEIMETSIQAMKRKVNLKTQQSQHPTDALSEDLLSIIANMSGCLPYMLPPKCPNTCLANKYRPITGACNNRDHPRWGASNTALARWLPPVYEDGFSQPRGWNPGFLYNGFPLPPVREVTRHVIQVSNEVVTDDDRYSDLLMAWGQYIDHDIAFTPQSTSKAAFGGGADCQMTCENQNPCFPIQLPEEARPAAGTACLPFYRSSAACGTGDQGALFGNLSTANPRQQMNGLTSFLDASTVYGSSPALERQLRNWTSAEGLLRVHARLRDSGRAYLPFVPPRAPAACAPEPGIPGETRGPCFLAGDGRASEVPSLTALHTLWLREHNRLAAALKALNAHWSADAVYQEARKVVGALHQIITLRDYIPRILGPEAFQQYVGPYEGYDSTANPTVSNVFSTAAFRFGHATIHPLVRRLDASFQEHPDLPGLWLHQAFFSPWTLLRGGGLDPLIRGLLARPAKLQVQDQLMNEELTERLFVLSNSSTLDLASINLQRGRDHGLPGYNEWREFCGLPRLETPADLSTAIASRSVADKILDLYKHPDNIDVWLGGLAENFLPRARTGPLFACLIGKQMKALRDGDWFWWENSHVFTDAQRRELEKHSLSRVICDNTGLTRVPMDAFQVGKFPEDFESCDSITGMNLEAWRETFPQDDKCGFPESVENGDFVHCEESGRRVLVYSCRHGYELQGREQLTCTQEGWDFQPPLCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVDSGRLPRVTWISMSLAALLIGGFAGLTSTVICRWTRTGTKSTLPISETGGGTPELRCGKHQAVGTSPQRAAAQDSEQESAGMEGRDTHRLPRAL
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P07202 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T52 | Phosphorylation | Uniprot | |
| Y55 | Phosphorylation | Uniprot | |
| T57 | Phosphorylation | Uniprot | |
| S97 | Phosphorylation | Uniprot | |
| T561 | Phosphorylation | Uniprot | |
| K879 | Ubiquitination | Uniprot | |
| T891 | Phosphorylation | Uniprot |
研究背景
Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).
Glycosylated.
Heme is covalently bound through a H(2)O(2)-dependent autocatalytic process. Heme insertion is important for the delivery of protein at the cell surface.
Cleaved in its N-terminal part.
Membrane>Single-pass type I membrane protein.
Cell surface.
Interacts with DUOX1, DUOX2 and CYBA.
Belongs to the peroxidase family. XPO subfamily.
研究領域
· Human Diseases > Immune diseases > Autoimmune thyroid disease.
· Metabolism > Amino acid metabolism > Tyrosine metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
· Organismal Systems > Endocrine system > Thyroid hormone synthesis.
参考文献
Application: WB Species: human Sample: TPC1 cells
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