BACH1 Antibody - #DF8317
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF8317, RRID:AB_2841595.
折りたたみ／展開
BACH 1; BACH 1.3; Bach1; BACH1_HUMAN; Basic leucine zipper transcription factor 1; basic region leucine zipper transcriptional regulator BACH1; BTB and CNC homolog 1; BTB and CNC homology 1; BTB and CNC homology 1, basic leucine zipper transcription factor 1; HA2303; OTTHUMP00000096563; OTTHUMP00000096564; Transcription regulator protein BACH1;
免疫原
- O14867 BACH1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSLSENSVFAYESSVHSTNVLLSLNDQRKKDVLCDVTIFVEGQRFRAHRSVLAACSSYFHSRIVGQADGELNITLPEEVTVKGFEPLIQFAYTAKLILSKENVDEVCKCVEFLSVHNIEESCFQFLKFKFLDSTADQQECPRKKCFSSHCQKTDLKLSLLDQRDLETDEVEEFLENKNVQTPQCKLRRYQGNAKASPPLQDSASQTYESMCLEKDAALALPSLCPKYRKFQKAFGTDRVRTGESSVKDIHASVQPNERSENECLGGVPECRDLQVMLKCDESKLAMEPEETKKDPASQCPTEKSEVTPFPHNSSIDPHGLYSLSLLHTYDQYGDLNFAGMQNTTVLTEKPLSGTDVQEKTFGESQDLPLKSDLGTREDSSVASSDRSSVEREVAEHLAKGFWSDICSTDTPCQMQLSPAVAKDGSEQISQKRSECPWLGIRISESPEPGQRTFTTLSSVNCPFISTLSTEGCSSNLEIGNDDYVSEPQQEPCPYACVISLGDDSETDTEGDSESCSAREQECEVKLPFNAQRIISLSRNDFQSLLKMHKLTPEQLDCIHDIRRRSKNRIAAQRCRKRKLDCIQNLESEIEKLQSEKESLLKERDHILSTLGETKQNLTGLCQKVCKEAALSQEQIQILAKYSAADCPLSFLISEKDKSTPDGELALPSIFSLSDRPPAVLPPCARGNSEPGYARGQESQQMSTATSEQAGPAEQCRQSGGISDFCQQMTDKCTTDE
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O14867 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K100 | Ubiquitination | Uniprot | |
| K129 | Ubiquitination | Uniprot | |
| K156 | Ubiquitination | Uniprot | |
| S158 | Phosphorylation | Uniprot | |
| K177 | Ubiquitination | Uniprot | |
| T181 | Phosphorylation | Uniprot | |
| K185 | Ubiquitination | Uniprot | |
| S196 | Phosphorylation | Uniprot | |
| K232 | Ubiquitination | Uniprot | |
| T236 | Phosphorylation | Uniprot | |
| K247 | Ubiquitination | Uniprot | |
| K359 | Ubiquitination | Uniprot | |
| T360 | Phosphorylation | Uniprot | |
| S364 | Phosphorylation | Uniprot | |
| K370 | Ubiquitination | Uniprot | |
| S379 | Phosphorylation | Uniprot | |
| S388 | Phosphorylation | Uniprot | |
| S417 | Phosphorylation | Uniprot | |
| S445 | Phosphorylation | Uniprot | |
| S504 | Phosphorylation | Uniprot | |
| T506 | Phosphorylation | Uniprot | |
| S543 | Phosphorylation | Uniprot | |
| K549 | Ubiquitination | Uniprot | |
| T551 | Phosphorylation | Uniprot | |
| K578 | Ubiquitination | Uniprot | |
| K596 | Ubiquitination | Uniprot | |
| K614 | Ubiquitination | Uniprot | |
| K626 | Ubiquitination | Uniprot | |
| K655 | Ubiquitination | Uniprot | |
| S688 | Phosphorylation | Uniprot | |
| C715 | S-Nitrosylation | Uniprot | |
| S718 | Phosphorylation | Uniprot |
研究背景
Transcriptional regulator that acts as repressor or activator, depending on the context. Binds to NF-E2 DNA binding sites. Plays important roles in coordinating transcription activation and repression by MAFK (By similarity). Together with MAF, represses the transcription of genes under the control of the NFE2L2 oxidative stress pathway.
Ubiquitinated by the SCF(FBXL17) complex, leading to its degradation by the proteasome.
Nucleus.
Heterodimer of BACH1 and MAFK.
Belongs to the bZIP family. CNC subfamily.
Restrictive clause
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