製品: KRT12 Antibody
カタログ: DF8321
タンパク質の説明: Rabbit polyclonal antibody to KRT12
アプリケーション: WB
反応性: Human, Mouse
予測: Pig, Bovine, Sheep, Rabbit, Dog
分子量: 54 kDa; 54kD(Calculated).
ユニプロット: Q99456
RRID: AB_2841597

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製品説明

ソース:
Rabbit
アプリケーション:
WB 1:1000-3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse
予測:
Pig(82%), Bovine(82%), Sheep(82%), Rabbit(91%), Dog(82%)
クローナリティ:
Polyclonal
特異性:
KRT12 Antibody detects endogenous levels of total KRT12.
RRID:
AB_2841597
引用形式: Affinity Biosciences Cat# DF8321, RRID:AB_2841597.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ/展開

CK-12; Cytokeratin-12; K12; K1C12_HUMAN; Keratin 12; Keratin; Keratin, type I cytoskeletal 12; Keratin-12; KRT12; type I cytoskeletal 12;

免疫原

免疫原:
Uniprot:
遺伝子(ID):
発現特異性:
Q99456 K1C12_HUMAN:

Cornea specific.

タンパク質配列:
MDLSNNTMSLSVRTPGLSRRLSSQSVIGRPRGMSASSVGSGYGGSAFGFGASCGGGFSAASMFGSSSGFGGGSGSSMAGGLGAGYGRALGGGSFGGLGMGFGGSPGGGSLGILSGNDGGLLSGSEKETMQNLNDRLASYLDKVRALEEANTELENKIREWYETRGTGTADASQSDYSKYYPLIEDLRNKIISASIGNAQLLLQIDNARLAAEDFRMKYENELALRQGVEADINGLRRVLDELTLTRTDLEMQIESLNEELAYMKKNHEDELQSFRVGGPGEVSVEMDAAPGVDLTRLLNDMRAQYETIAEQNRKDAEAWFIEKSGELRKEISTNTEQLQSSKSEVTDLRRAFQNLEIELQSQLAMKKSLEDSLAEAEGDYCAQLSQVQQLISNLEAQLLQVRADAERQNVDHQRLLNVKARLELEIETYRRLLDGEAQGDGLEESLFVTDSKSQAQSTDSSKDPTKTRKIKTVVQEMVNGEVVSSQVQEIEELM

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Rabbit
91
Pig
82
Bovine
82
Sheep
82
Dog
82
Horse
73
Xenopus
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q99456 基板として

Site PTM Type Enzyme
S22 Phosphorylation
S138 Phosphorylation
Y139 Phosphorylation
K142 Acetylation
K142 Ubiquitination
Y161 Phosphorylation
T163 Phosphorylation
K189 Ubiquitination
Y262 Phosphorylation
S343 Phosphorylation
Y429 Phosphorylation

研究背景

機能:

May play a unique role in maintaining the normal corneal epithelial function. Together with KRT3, essential for the maintenance of corneal epithelium integrity (By similarity).

組織特異性:

Cornea specific.

サブユニット構造:

Heterotetramer of two type I and two type II keratins. Keratin-3 associates with keratin-12.

タンパク質ファミリー:

Belongs to the intermediate filament family.

研究領域

· Organismal Systems > Endocrine system > Estrogen signaling pathway.   (View pathway)

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