TXNRD1 Antibody - #DF8339
| 製品: | TXNRD1 Antibody |
| カタログ: | DF8339 |
| タンパク質の説明: | Rabbit polyclonal antibody to TXNRD1 |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 55 kDa; 71kD(Calculated). |
| ユニプロット: | Q16881 |
| RRID: | AB_2841607 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF8339, RRID:AB_2841607.
折りたたみ／展開
cytoplasmic; Gene associated with retinoic and IFN-induced mortality 12 protein; Gene associated with retinoic and interferon-induced mortality 12 protein; Gene associated with retinoid IFN induced mortality 12 protein; GRIM 12; GRIM-12; GRIM12; KDRF; KM 102 derived reductase like factor; KM-102-derived reductase-like factor; MGC9145; Oxidoreductase; Thioredoxin reductase 1; Thioredoxin reductase 1 cytoplasmic; Thioredoxin reductase GRIM 12; Thioredoxin reductase TR1; TR 1; TR; TR1; TRXR 1; TRXR1; TRXR1_HUMAN; TXNR; TXNRD 1; Txnrd1;
免疫原
A synthesized peptide derived from human TXNRD1, corresponding to a region within the internal amino acids.
Isoform 1 is expressed predominantly in Leydig cells (at protein level). Also expressed in ovary, spleen, heart, liver, kidney and pancreas and in a number of cancer cell lines. Isoform 4 is widely expressed with highest levels in kidney, testis, uterus, ovary, prostate, placenta and fetal liver.
- Q16881 TRXR1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGCAEGKAVAAAAPTELQTKGKNGDGRRRSAKDHHPGKTLPENPAGFTSTATADSRALLQAYIDGHSVVIFSRSTCTRCTEVKKLFKSLCVPYFVLELDQTEDGRALEGTLSELAAETDLPVVFVKQRKIGGHGPTLKAYQEGRLQKLLKMNGPEDLPKSYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKLMHQAALLGQALQDSRNYGWKVEETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYENAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDYENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDNNKCYAKIICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSVTKRSGASILQAGCUG
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q16881 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T39 | Phosphorylation | Uniprot | |
| T50 | Phosphorylation | Uniprot | |
| K126 | Ubiquitination | Uniprot | |
| K129 | Ubiquitination | Uniprot | |
| K138 | Methylation | Uniprot | |
| K138 | Ubiquitination | Uniprot | |
| K147 | Ubiquitination | Uniprot | |
| K150 | Methylation | Uniprot | |
| S160 | Phosphorylation | Uniprot | |
| Y161 | Phosphorylation | Uniprot | |
| Y163 | Phosphorylation | Uniprot | |
| K179 | Ubiquitination | Uniprot | |
| Y184 | Phosphorylation | Uniprot | |
| K187 | Ubiquitination | Uniprot | |
| T195 | Phosphorylation | Uniprot | |
| T197 | Phosphorylation | Uniprot | |
| K217 | Ubiquitination | Uniprot | |
| K218 | Ubiquitination | Uniprot | |
| K239 | Acetylation | Uniprot | |
| K239 | Ubiquitination | Uniprot | |
| K245 | Acetylation | Uniprot | |
| K245 | Ubiquitination | Uniprot | |
| K274 | Ubiquitination | Uniprot | |
| Y277 | Phosphorylation | Uniprot | |
| Y281 | Phosphorylation | Uniprot | |
| K291 | Ubiquitination | Uniprot | |
| K298 | Acetylation | Uniprot | |
| K300 | Ubiquitination | Uniprot | |
| K324 | Ubiquitination | Uniprot | |
| K385 | Ubiquitination | Uniprot | |
| K396 | Ubiquitination | Uniprot | |
| K405 | Acetylation | Uniprot | |
| K405 | Sumoylation | Uniprot | |
| K405 | Ubiquitination | Uniprot | |
| T413 | Phosphorylation | Uniprot | |
| Y434 | Phosphorylation | Uniprot | |
| K449 | Ubiquitination | Uniprot | |
| K458 | Ubiquitination | Uniprot | |
| K462 | Ubiquitination | Uniprot | |
| K465 | Ubiquitination | Uniprot | |
| T469 | Phosphorylation | Uniprot | |
| T474 | Phosphorylation | Uniprot | |
| Y478 | Phosphorylation | Uniprot | |
| K489 | Ubiquitination | Uniprot | |
| T493 | Phosphorylation | Uniprot | |
| K514 | Ubiquitination | Uniprot | |
| K539 | Ubiquitination | Uniprot | |
| Y555 | Phosphorylation | Uniprot | |
| Y572 | Phosphorylation | Uniprot | |
| K574 | Ubiquitination | Uniprot | |
| K580 | Ubiquitination | Uniprot | |
| K607 | Ubiquitination | Uniprot | |
| K613 | Ubiquitination | Uniprot | |
| C647 | S-Nitrosylation | Uniprot |
研究背景
Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid.
The N-terminus of isoform 5 is blocked.
ISGylated.
Cytoplasm.
Cytoplasm. Nucleus.
Cytoplasm.
Isoform 1 is expressed predominantly in Leydig cells (at protein level). Also expressed in ovary, spleen, heart, liver, kidney and pancreas and in a number of cancer cell lines. Isoform 4 is widely expressed with highest levels in kidney, testis, uterus, ovary, prostate, placenta and fetal liver.
Homodimer. Isoform 4 interacts with ESR1 and ESR2. Interacts with HERC5.
The N-terminal glutaredoxin domain found in isoform 1 does not contain the C-P-Y-C redox-active motif normally found in glutaredoxins and has been found to be inactive in classical glutaredoxin assays.
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
研究領域
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Human Diseases > Cancers: Specific types > Hepatocellular carcinoma. (View pathway)
· Metabolism > Metabolism of other amino acids > Selenocompound metabolism.
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