MCRS1 Antibody - #DF8361
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF8361, RRID:AB_2841626.
折りたたみ／展開
58 kDa microspherule protein; Cell cycle regulated factor (78 kDa); Cell cycle regulated factor p78; Cell cycle-regulated factor p78; ICP22BP; INO80 complex subunit J; MCRS 1; MCRS 2; MCRS1; MCRS1_HUMAN; MCRS2; Microspherule protein 1; MSP 58; MSP58; p78;
免疫原
Detected in testis, and at lower levels in spleen, thymus, prostate, uterus, small intestine, colon and leukocytes.
- Q96EZ8 MCRS1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDKDSQGLLDSSLMASGTASRSEDEESLAGQKRASSQALGTIPKRRSSSRFIKRKKFDDELVESSLAKSSTRAKGASGVEPGRCSGSEPSSSEKKKVSKAPSTPVPPSPAPAPGLTKRVKKSKQPLQVTKDLGRWKPADDLLLINAVLQTNDLTSVHLGVKFSCRFTLREVQERWYALLYDPVISKLACQAMRQLHPEAIAAIQSKALFSKAEEQLLSKVGSTSQPTLETFQDLLHRHPDAFYLARTAKALQAHWQLMKQYYLLEDQTVQPLPKGDQVLNFSDAEDLIDDSKLKDMRDEVLEHELMVADRRQKREIRQLEQELHKWQVLVDSITGMSSPDFDNQTLAVLRGRMVRYLMRSREITLGRATKDNQIDVDLSLEGPAWKISRKQGVIKLKNNGDFFIANEGRRPIYIDGRPVLCGSKWRLSNNSVVEIASLRFVFLINQDLIALIRAEAAKITPQ
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q96EZ8 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| S20 | Phosphorylation | Uniprot | |
| S22 | Phosphorylation | Uniprot | |
| S27 | Phosphorylation | Uniprot | |
| K32 | Acetylation | Uniprot | |
| S35 | Phosphorylation | Uniprot | |
| S36 | Phosphorylation | Uniprot | |
| S48 | Phosphorylation | Uniprot | |
| K56 | Sumoylation | Uniprot | |
| K74 | Methylation | Uniprot | |
| S85 | Phosphorylation | Uniprot | |
| S98 | Phosphorylation | Uniprot | |
| S102 | Phosphorylation | Uniprot | |
| T103 | Phosphorylation | Uniprot | |
| S108 | Phosphorylation | Uniprot | |
| T116 | Phosphorylation | Uniprot | |
| K117 | Ubiquitination | Uniprot | |
| K123 | Acetylation | Uniprot | |
| K130 | Acetylation | Uniprot | |
| K130 | Ubiquitination | Uniprot | |
| K206 | Ubiquitination | Uniprot | |
| K211 | Ubiquitination | Uniprot | |
| K219 | Ubiquitination | Uniprot | |
| S282 | Phosphorylation | Uniprot | |
| K292 | Ubiquitination | Uniprot | |
| K370 | Ubiquitination | Uniprot | |
| K397 | Ubiquitination | Uniprot | |
| K458 | Ubiquitination | Uniprot | |
| T460 | Phosphorylation | Uniprot |
研究背景
Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity. Binds to G-quadruplex structures in mRNA. Binds to RNA homopolymer poly(G) and poly(U).
Nucleus. Nucleus>Nucleolus. Cytoplasm.
Note: In microspherules in the nucleolus.
Detected in testis, and at lower levels in spleen, thymus, prostate, uterus, small intestine, colon and leukocytes.
Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the N-terminus of INO80. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1. Interacts with NOP2. Interacts with PINX1. Interacts with TERT. Interacts with CCDC85B. Interacts with DAXX. Interacts (via N-terminus) with FMR1 (via phosphorylated form). Interacts with FXR1 AND FXR2.
(Microbial infection) Interacts with Herpes simplex virus ICP22.
研究領域
· Human Diseases > Infectious diseases: Viral > Herpes simplex infection.
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