LSS Antibody - #DF8379
| 製品: | LSS Antibody |
| カタログ: | DF8379 |
| タンパク質の説明: | Rabbit polyclonal antibody to LSS |
| アプリケーション: | WB IHC |
| 反応性: | Human, Monkey |
| 予測: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 83 kDa; 83kD(Calculated). |
| ユニプロット: | P48449 |
| RRID: | AB_2841641 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF8379, RRID:AB_2841641.
折りたたみ／展開
2,3 epoxysqualene lanosterol cyclase; hOSC; Lanosterol synthase (2,3 oxidosqualene lanosterol cyclase); Lanosterol synthase; OSC; Oxidosqualene lanosterol cyclase;
免疫原
Widely expressed. Expressed in the hair bulb, the outer root sheath and hair matrix of the hair follicle epithelium. Also detected in dermal papilla, epidermis, sweat glands, sebaceous glands, and blood vessels.
- P48449 ERG7_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTEGTCLRRRGGPYKTEPATDLGRWRLNCERGRQTWTYLQDERAGREQTGLEAYALGLDTKNYFKDLPKAHTAFEGALNGMTFYVGLQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLPAGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVSLRILGVGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQVYLPMSYCYAVRLSAAEDPLVQSLRQELYVEDFASIDWLAQRNNVAPDELYTPHSWLLRVVYALLNLYEHHHSAHLRQRAVQKLYEHIVADDRFTKSISIGPISKTINMLVRWYVDGPASTAFQEHVSRIPDYLWMGLDGMKMQGTNGSQIWDTAFAIQALLEAGGHHRPEFSSCLQKAHEFLRLSQVPDNPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLLLQEKCPHVTEHIPRERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKYFHKRFPEHRAAEIRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDGTACAEVSRACDFLLSRQMADGGWGEDFESCEERRYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGVFNKSCAISYTSYRNIFPIWALGRFSQLYPERALAGHP
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P48449 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T2 | Acetylation | Uniprot | |
| R10 | Methylation | Uniprot | |
| K15 | Ubiquitination | Uniprot | |
| K61 | Ubiquitination | Uniprot | |
| K65 | Ubiquitination | Uniprot | |
| K148 | Ubiquitination | Uniprot | |
| Y158 | Phosphorylation | Uniprot | |
| K194 | Acetylation | Uniprot | |
| S249 | Phosphorylation | Uniprot | |
| S258 | Phosphorylation | Uniprot | |
| K318 | Ubiquitination | Uniprot | |
| Y320 | Phosphorylation | Uniprot | |
| K331 | Ubiquitination | Uniprot | |
| S334 | Phosphorylation | Uniprot | |
| K340 | Ubiquitination | Uniprot | |
| Y368 | Phosphorylation | Uniprot | |
| K432 | Ubiquitination | Uniprot | |
| K439 | Ubiquitination | Uniprot | |
| K470 | Ubiquitination | Uniprot | |
| T475 | Phosphorylation | Uniprot | |
| K506 | Ubiquitination | Uniprot | |
| K680 | Ubiquitination | Uniprot | |
| K698 | Ubiquitination | Uniprot |
研究背景
Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens protein aggregation and increase transparency.
Endoplasmic reticulum membrane>Peripheral membrane protein.
Widely expressed. Expressed in the hair bulb, the outer root sheath and hair matrix of the hair follicle epithelium. Also detected in dermal papilla, epidermis, sweat glands, sebaceous glands, and blood vessels.
Monomer.
Belongs to the terpene cyclase/mutase family.
研究領域
· Metabolism > Lipid metabolism > Steroid biosynthesis.
· Metabolism > Global and overview maps > Metabolic pathways.
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.