DOCK2 Antibody - #DF8431
製品: | DOCK2 Antibody |
カタログ: | DF8431 |
タンパク質の説明: | Rabbit polyclonal antibody to DOCK2 |
アプリケーション: | WB IF/ICC |
反応性: | Human |
予測: | Pig, Bovine, Horse, Rabbit, Dog, Chicken |
分子量: | 212 kDa; 212kD(Calculated). |
ユニプロット: | Q92608 |
RRID: | AB_2841679 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF8431, RRID:AB_2841679.
折りたたみ/展開
Dedicator of cyto kinesis 2; Dedicator of cytokinesis 2; Dedicator of cytokinesis protein 2; DOCK 2; FLJ46592; KIAA0209;
免疫原
Specifically expressed in hematopoietic cells. Highly expressed in peripheral blood leukocytes, and expressed at intermediate level in thymus and spleen. Expressed at very low level in the small intestine and colon.
- Q92608 DOCK2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAPWRKADKERHGVAIYNFQGSGAPQLSLQIGDVVRIQETCGDWYRGYLIKHKMLQGIFPKSFIHIKEVTVEKRRNTENIIPAEIPLAQEVTTTLWEWGSIWKQLYVASKKERFLQVQSMMYDLMEWRSQLLSGTLPKDELKELKQKVTSKIDYGNKILELDLIVRDEDGNILDPDNTSVISLFHAHEEATDKITERIKEEMSKDQPDYAMYSRISSSPTHSLYVFVRNFVCRIGEDAELFMSLYDPNKQTVISENYLVRWGSRGFPKEIEMLNNLKVVFTDLGNKDLNRDKIYLICQIVRVGKMDLKDTGAKKCTQGLRRPFGVAVMDITDIIKGKAESDEEKQHFIPFHPVTAENDFLHSLLGKVIASKGDSGGQGLWVTMKMLVGDIIQIRKDYPHLVDRTTVVARKLGFPEIIMPGDVRNDIYITLLQGDFDKYNKTTQRNVEVIMCVCAEDGKTLPNAICVGAGDKPMNEYRSVVYYQVKQPRWMETVKVAVPIEDMQRIHLRFMFRHRSSLESKDKGEKNFAMSYVKLMKEDGTTLHDGFHDLVVLKGDSKKMEDASAYLTLPSYRHHVENKGATLSRSSSSVGGLSVSSRDVFSISTLVCSTKLTQNVGLLGLLKWRMKPQLLQENLEKLKIVDGEEVVKFLQDTLDALFNIMMEHSQSDEYDILVFDALIYIIGLIADRKFQHFNTVLEAYIQQHFSATLAYKKLMTVLKTYLDTSSRGEQCEPILRTLKALEYVFKFIVRSRTLFSQLYEGKEQMEFEESMRRLFESINNLMKSQYKTTILLQVAALKYIPSVLHDVEMVFDAKLLSQLLYEFYTCIPPVKLQKQKVQSMNEIVQSNLFKKQECRDILLPVITKELKELLEQKDDMQHQVLERKYCVELLNSILEVLSYQDAAFTYHHIQEIMVQLLRTVNRTVITMGRDHILISHFVACMTAILNQMGDQHYSFYIETFQTSSELVDFLMETFIMFKDLIGKNVYPGDWMAMSMVQNRVFLRAINKFAETMNQKFLEHTNFEFQLWNNYFHLAVAFITQDSLQLEQFSHAKYNKILNKYGDMRRLIGFSIRDMWYKLGQNKICFIPGMVGPILEMTLIPEAELRKATIPIFFDMMLCEYQRSGDFKKFENEIILKLDHEVEGGRGDEQYMQLLESILMECAAEHPTIAKSVENFVNLVKGLLEKLLDYRGVMTDESKDNRMSCTVNLLNFYKDNNREEMYIRYLYKLRDLHLDCDNYTEAAYTLLLHTWLLKWSDEQCASQVMQTGQQHPQTHRQLKETLYETIIGYFDKGKMWEEAISLCKELAEQYEMEIFDYELLSQNLIQQAKFYESIMKILRPKPDYFAVGYYGQGFPSFLRNKVFIYRGKEYERREDFQMQLMTQFPNAEKMNTTSAPGDDVKNAPGQYIQCFTVQPVLDEHPRFKNKPVPDQIINFYKSNYVQRFHYSRPVRRGTVDPENEFASMWIERTSFVTAYKLPGILRWFEVVHMSQTTISPLENAIETMSTANEKILMMINQYQSDETLPINPLSMLLNGIVDPAVMGGFAKYEKAFFTEEYVRDHPEDQDKLTHLKDLIAWQIPFLGAGIKIHEKRVSDNLRPFHDRMEECFKNLKMKVEKEYGVREMPDFDDRRVGRPRSMLRSYRQMSIISLASMNSDCSTPSKPTSESFDLELASPKTPRVEQEEPISPGSTLPEVKLRRSKKRTKRSSVVFADEKAAAESDLKRLSRKHEFMSDTNLSEHAAIPLKASVLSQMSFASQSMPTIPALALSVAGIPGLDEANTSPRLSQTFLQLSDGDKKTLTRKKVNQFFKTMLASKSAEEGKQIPDSLSTDL
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q92608 基板として
Site | PTM Type | Enzyme | Source |
---|---|---|---|
Y48 | Phosphorylation | Uniprot | |
K51 | Ubiquitination | Uniprot | |
K53 | Ubiquitination | Uniprot | |
K61 | Ubiquitination | Uniprot | |
K67 | Acetylation | Uniprot | |
K67 | Ubiquitination | Uniprot | |
K110 | Ubiquitination | Uniprot | |
K138 | Ubiquitination | Uniprot | |
K145 | Acetylation | Uniprot | |
K151 | Acetylation | Uniprot | |
K151 | Ubiquitination | Uniprot | |
K199 | Ubiquitination | Uniprot | |
S203 | Phosphorylation | Uniprot | |
K204 | Ubiquitination | Uniprot | |
Y209 | Phosphorylation | Uniprot | |
Y212 | Phosphorylation | Uniprot | |
S213 | Phosphorylation | Uniprot | |
S218 | Phosphorylation | Uniprot | |
S222 | Phosphorylation | Uniprot | |
K268 | Ubiquitination | Uniprot | |
K277 | Ubiquitination | Uniprot | |
T281 | Phosphorylation | Uniprot | |
K286 | Ubiquitination | Uniprot | |
K304 | Acetylation | Uniprot | |
K304 | Ubiquitination | Uniprot | |
K308 | Ubiquitination | Uniprot | |
T331 | Phosphorylation | Uniprot | |
K337 | Ubiquitination | Uniprot | |
K344 | Ubiquitination | Uniprot | |
K366 | Ubiquitination | Uniprot | |
K371 | Ubiquitination | Uniprot | |
K395 | Ubiquitination | Uniprot | |
K410 | Ubiquitination | Uniprot | |
K437 | Ubiquitination | Uniprot | |
K440 | Ubiquitination | Uniprot | |
K471 | Ubiquitination | Uniprot | |
Y481 | Phosphorylation | Uniprot | |
Y482 | Phosphorylation | Uniprot | |
K485 | Ubiquitination | Uniprot | |
K494 | Ubiquitination | Uniprot | |
K525 | Ubiquitination | Uniprot | |
K533 | Ubiquitination | Uniprot | |
K536 | Ubiquitination | Uniprot | |
K553 | Ubiquitination | Uniprot | |
K557 | Methylation | Uniprot | |
K558 | Ubiquitination | Uniprot | |
K578 | Ubiquitination | Uniprot | |
S585 | Phosphorylation | Uniprot | |
S586 | Phosphorylation | Uniprot | |
S587 | Phosphorylation | Uniprot | |
S588 | Phosphorylation | Uniprot | |
S593 | Phosphorylation | Uniprot | |
K610 | Ubiquitination | Uniprot | |
T612 | Phosphorylation | Uniprot | |
K622 | Ubiquitination | Uniprot | |
K626 | Ubiquitination | Uniprot | |
K636 | Ubiquitination | Uniprot | |
K638 | Ubiquitination | Uniprot | |
Y699 | Phosphorylation | Uniprot | |
K712 | Ubiquitination | Uniprot | |
K738 | Acetylation | Uniprot | |
S755 | Phosphorylation | Uniprot | |
Y758 | Phosphorylation | Uniprot | |
Y798 | Phosphorylation | Uniprot | |
S801 | Phosphorylation | Uniprot | |
K835 | Ubiquitination | Uniprot | |
S838 | Phosphorylation | Uniprot | |
K849 | Ubiquitination | Uniprot | |
K850 | Ubiquitination | Uniprot | |
K863 | Ubiquitination | Uniprot | |
K866 | Ubiquitination | Uniprot | |
K872 | Ubiquitination | Uniprot | |
K1006 | Ubiquitination | Uniprot | |
K1054 | Ubiquitination | Uniprot | |
K1058 | Acetylation | Uniprot | |
K1058 | Ubiquitination | Uniprot | |
K1076 | Ubiquitination | Uniprot | |
Y1119 | Phosphorylation | Uniprot | |
K1127 | Ubiquitination | Uniprot | |
K1135 | Ubiquitination | Uniprot | |
T1166 | Phosphorylation | Uniprot | |
S1170 | Phosphorylation | Uniprot | |
K1179 | Ubiquitination | Uniprot | |
K1184 | Ubiquitination | Uniprot | |
K1197 | Ubiquitination | Uniprot | |
Y1220 | Phosphorylation | Uniprot | |
K1226 | Ubiquitination | Uniprot | |
S1260 | Phosphorylation | Uniprot | |
K1290 | Ubiquitination | Uniprot | |
K1292 | Ubiquitination | Uniprot | |
S1354 | Phosphorylation | Uniprot | |
K1359 | Ubiquitination | Uniprot | |
K1387 | Ubiquitination | Uniprot | |
T1390 | Phosphorylation | Uniprot | |
T1391 | Phosphorylation | Uniprot | |
S1392 | Phosphorylation | Uniprot | |
K1399 | Ubiquitination | Uniprot | |
K1422 | Ubiquitination | Uniprot | |
K1424 | Ubiquitination | Uniprot | |
Y1434 | Phosphorylation | Uniprot | |
K1435 | Ubiquitination | Uniprot | |
S1436 | Phosphorylation | Uniprot | |
K1474 | Ubiquitination | Uniprot | |
S1488 | Phosphorylation | Uniprot | |
K1548 | Ubiquitination | Uniprot | |
Y1555 | Phosphorylation | Uniprot | |
K1565 | Ubiquitination | Uniprot | |
K1570 | Ubiquitination | Uniprot | |
S1592 | Phosphorylation | Uniprot | |
R1601 | Methylation | Uniprot | |
K1607 | Ubiquitination | Uniprot | |
K1612 | Ubiquitination | Uniprot | |
K1615 | Ubiquitination | Uniprot | |
Y1617 | Phosphorylation | Uniprot | |
S1635 | Phosphorylation | Uniprot | |
S1639 | Phosphorylation | Uniprot | |
S1644 | Phosphorylation | Uniprot | |
T1657 | Phosphorylation | Uniprot | |
S1672 | Phosphorylation | Uniprot | |
T1675 | Phosphorylation | Uniprot | |
S1685 | Phosphorylation | Uniprot | |
S1688 | Phosphorylation | Uniprot | |
T1689 | Phosphorylation | Uniprot | |
K1694 | Ubiquitination | Uniprot | |
S1698 | Phosphorylation | Uniprot | |
T1702 | Phosphorylation | Uniprot | |
S1705 | Phosphorylation | Uniprot | |
S1706 | Phosphorylation | Uniprot | |
K1713 | Ubiquitination | Uniprot | |
K1721 | Ubiquitination | Uniprot | |
S1724 | Phosphorylation | Uniprot | |
K1726 | Ubiquitination | Uniprot | |
S1731 | Phosphorylation | Uniprot | |
T1733 | Phosphorylation | Uniprot | |
S1736 | Phosphorylation | Uniprot | |
S1757 | Phosphorylation | Uniprot | |
S1780 | Phosphorylation | Uniprot | |
S1784 | Phosphorylation | Uniprot | |
T1786 | Phosphorylation | Uniprot | |
S1791 | Phosphorylation | Uniprot | |
K1795 | Ubiquitination | Uniprot | |
K1796 | Ubiquitination | Uniprot | |
T1797 | Phosphorylation | Uniprot | |
T1799 | Phosphorylation | Uniprot | |
K1802 | Ubiquitination | Uniprot | |
K1808 | Ubiquitination | Uniprot | |
T1809 | Phosphorylation | Uniprot | |
K1814 | Ubiquitination | Uniprot | |
K1820 | Ubiquitination | Uniprot |
研究背景
Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2.
Endomembrane system>Peripheral membrane protein. Cytoplasm>Cytoskeleton.
Note: Colocalizes with F-actin.
Specifically expressed in hematopoietic cells. Highly expressed in peripheral blood leukocytes, and expressed at intermediate level in thymus and spleen. Expressed at very low level in the small intestine and colon.
Homodimer (Probable). Interacts with RAC1 and RAC2. Interacts with CRKL and VAV. Interacts with CD3Z.
The DHR-2 domain may mediate the GEF activity.
Belongs to the DOCK family.
研究領域
· Organismal Systems > Immune system > Chemokine signaling pathway. (View pathway)
· Organismal Systems > Immune system > Fc gamma R-mediated phagocytosis. (View pathway)
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