CD42b Antibody - #DF8519
| 製品: | CD42b Antibody |
| カタログ: | DF8519 |
| タンパク質の説明: | Rabbit polyclonal antibody to CD42b |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse |
| 予測: | Bovine, Rabbit, Dog |
| 分子量: | 70kD, 100~140kD; 72kD(Calculated). |
| ユニプロット: | P07359 |
| RRID: | AB_2841724 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF8519, RRID:AB_2841724.
折りたたみ／展開
Antigen CD42b alpha; BDPLT1; BDPLT3; BSS; CD 42b; CD42b alpha; CD42B; CD42b antigen; DBPLT3; GLYCOCALICIN; Glycoprotein Ib (platelet) alpha polypeptide; Glycoprotein Ibalpha; GP Ib alpha; GP1B; GP1BA; GPIb alpha; GPIbA; MGC34595; Platelet glycoprotein Ib alpha chain; Platelet glycoprotein Ib alpha polypeptide; Platelet membrane glycoprotein 1b alpha subunit; VWDP;
免疫原
- P07359 GP1BA_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPLLLLLLLLPSPLHPHPICEVSKVASHLEVNCDKRNLTALPPDLPKDTTILHLSENLLYTFSLATLMPYTRLTQLNLDRCELTKLQVDGTLPVLGTLDLSHNQLQSLPLLGQTLPALTVLDVSFNRLTSLPLGALRGLGELQELYLKGNELKTLPPGLLTPTPKLEKLSLANNNLTELPAGLLNGLENLDTLLLQENSLYTIPKGFFGSHLLPFAFLHGNPWLCNCEILYFRRWLQDNAENVYVWKQGVDVKAMTSNVASVQCDNSDKFPVYKYPGKGCPTLGDEGDTDLYDYYPEEDTEGDKVRATRTVVKFPTKAHTTPWGLFYSWSTASLDSQMPSSLHPTQESTKEQTTFPPRWTPNFTLHMESITFSKTPKSTTEPTPSPTTSEPVPEPAPNMTTLEPTPSPTTPEPTSEPAPSPTTPEPTSEPAPSPTTPEPTSEPAPSPTTPEPTPIPTIATSPTILVSATSLITPKSTFLTTTKPVSLLESTKKTIPELDQPPKLRGVLQGHLESSRNDPFLHPDFCCLLPLGFYVLGLFWLLFASVVLILLLSWVGHVKPQALDSGQGAALTTATQTTHLELQRGRQVTVPRAWLLFLRGSLPTFRSSLFLWVRPNGRVGPLVAGRRPSALSQGRGQDLLSTVSIRYSGHSL
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P07359 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| N37 | N-Glycosylation | Uniprot | |
| T129 | Phosphorylation | Uniprot | |
| S130 | Phosphorylation | Uniprot | |
| T163 | Phosphorylation | Uniprot | |
| N175 | N-Glycosylation | Uniprot | |
| Y292 | Phosphorylation | Uniprot | |
| Y294 | Phosphorylation | Uniprot | |
| Y295 | Phosphorylation | Uniprot | |
| K304 | Acetylation | Uniprot | |
| T308 | O-Glycosylation | Uniprot | |
| T360 | Phosphorylation | Uniprot | |
| S601 | Phosphorylation | Uniprot | |
| S607 | Phosphorylation | Uniprot | |
| S629 | Phosphorylation | Uniprot | |
| S632 | Phosphorylation | Uniprot | |
| S651 | Phosphorylation | Uniprot |
研究背景
GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium.
Glycocalicin is the product of a proteolytic cleavage/shedding, catalyzed by ADAM17, which releases most of the extracellular domain. Binding sites for vWF and thrombin are in this part of the protein.
Membrane>Single-pass type I membrane protein.
Two GP-Ib beta are disulfide-linked to one GP-Ib alpha. GP-IX is complexed with the GP-Ib heterodimer via a non covalent linkage. Interacts with FLNB. Interacts with FLNA (via filamin repeats 4, 9, 12, 17, 19, 21, and 23).
(Microbial infection) Interacts with Staphylococcus aureus protein SSL5.
研究領域
· Environmental Information Processing > Signaling molecules and interaction > ECM-receptor interaction. (View pathway)
· Organismal Systems > Immune system > Platelet activation. (View pathway)
· Organismal Systems > Immune system > Hematopoietic cell lineage. (View pathway)
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