Defensin alpha1 Antibody - #DF8527

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製品: Defensin alpha1 Antibody
カタログ: DF8527
タンパク質の説明: Rabbit polyclonal antibody to Defensin alpha1
アプリケーション: WB IHC
反応性: Human, Mouse
分子量: 10 kDa; 10kD(Calculated).
ユニプロット: P59665
RRID: AB_2841731

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MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:1000-3000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse
クローナリティ:
Polyclonal
特異性:
Defensin alpha1 Antibody detects endogenous levels of total Defensin alpha1.
RRID:
AB_2841731
引用形式: Affinity Biosciences Cat# DF8527, RRID:AB_2841731.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

DEF1; DEF3; DEFA1; DEFA2; DEFA3; Defensin alpha 1; Defensin alpha 2; Defensin alpha 3; HNP1; HNP3; HP1; HP3; MRS; Neutrophil defensin 1; Neutrophil defensin 2; Neutrophil defensin 3;

免疫原

免疫原:
Uniprot:

P59665(DEF1_HUMAN) >>Visit HPA database.

遺伝子(ID):
DEFA1; DEFA1B(1667)
タンパク質配列:
MRTLAILAAILLVALQAQAEPLQARADEVAAAPEQIAADIPEVVVSLAWDESLAPKHPGSRKNMACYCRIPACIAGERRYGTCIYQGRLWAFCC

PTMs - P59665 基板として

Site PTM Type Enzyme
Y67 Phosphorylation
Y80 Phosphorylation
T82 Phosphorylation
C83 S-Nitrosylation
Y85 Phosphorylation

研究背景

機能:

Defensin 1 and defensin 2 have antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane.

PTMs:

ADP-ribosylation drastically reduces cytotoxic and antibacterial activities, and enhances IL8 production.

Phosphorylation at Tyr-85 has been found in some cancer cell lines, and interferes with ADP-ribosylation.

細胞の位置付け:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
サブユニット構造:

Dimer. Interacts with RETN.

タンパク質ファミリー:

Belongs to the alpha-defensin family.

参考文献

1). Genetically Engineered Goats as Efficient Mammary Gland Bioreactors for Production of Recombinant Human Neutrophil Peptide 1 Using CRISPR/Cas9. Biology, 2024 (PubMed: 38927247) [IF=4.2]

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