Defensin beta-2 Antibody - #DF8531

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製品: Defensin beta-2 Antibody
カタログ: DF8531
タンパク質の説明: Rabbit polyclonal antibody to Defensin beta-2
アプリケーション: WB IF/ICC
反応性: Human
分子量: 7 kDa; 7kD(Calculated).
ユニプロット: O15263
RRID: AB_2841735

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MS Report
HPLC Report
MSDS
説明書
COA
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WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:1000-3000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human
クローナリティ:
Polyclonal
特異性:
Defensin beta-2 Antibody detects endogenous levels of total Defensin beta-2.
RRID:
AB_2841735
引用形式: Affinity Biosciences Cat# DF8531, RRID:AB_2841735.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

BD 2; BD-2; BD2; beta 2; Beta defensin 2; Beta defensin 4B; Beta-defensin 2; Beta-defensin 4A; DEF B2; DEF B4; DEFB 102; DEFB 2; DEFB 4; DEFB102; DEFB2; DEFB2, formerly; DEFB4; DEFB4, formerly; DEFB4B; DEFB4P; Defensin; Defensin beta 2; Defensin, beta 4; Defensin, beta 4, pseudogene; Defensin, beta 4A; Defensin, beta 4B; Defensin, beta, 2, formerly; Defensin, beta, 4, formerly; DFB4A_HUMAN; HBD 2; hBD-2; HBD2; mBD-2; SAP 1; SAP1; Skin antimicrobial peptide 1; Skin-antimicrobial peptide 1;

免疫原

免疫原:
Uniprot:

O15263(DFB4A_HUMAN) >>Visit HPA database.

遺伝子(ID):
DEFB4A; DEFB4B(100289462)
発現特異性:
O15263 DFB4A_HUMAN:

Expressed in the skin and respiratory tract.

タンパク質配列:
MRVLYLLFSFLFIFLMPLPGVFGGIGDPVTCLKSGAICHPVFCPRRYKQIGTCGLPGTKCCKKP

研究背景

機能:

Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria. May act as a ligand for C-C chemokine receptor CCR6. Can bind to both human and mouse CCR6 and induce chemotactic activity of CCR6-expressing cells.

細胞の位置付け:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Expressed in the skin and respiratory tract.

タンパク質ファミリー:

Belongs to the beta-defensin family. LAP/TAP subfamily.

研究領域

· Organismal Systems > Immune system > IL-17 signaling pathway.   (View pathway)

参考文献

1). Increased S. Aureus Colonization and Reduced Antimicrobial Peptide Expression in Erythrodermic Psoriasis. International immunopharmacology, 2024 (PubMed: 38096593) [IF=4.8]

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