ECP Antibody - #DF8536
| 製品: | ECP Antibody |
| カタログ: | DF8536 |
| タンパク質の説明: | Rabbit polyclonal antibody to ECP |
| アプリケーション: | WB IHC |
| 反応性: | Human, Monkey |
| 分子量: | 18 kDa; 18kD(Calculated). |
| ユニプロット: | P12724 |
| RRID: | AB_2841740 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF8536, RRID:AB_2841740.
折りたたみ／展開
Cytotoxic ribonuclease; ECP; ECP_HUMAN; Eosinophil cationic protein; OTTHUMP00000164017; Ribonuclease 3; Ribonuclease, RNase A family, 3; RNase 3; RNASE3; RNS3;
免疫原
- P12724 ECP_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MVPKLFTSQICLLLLLGLMGVEGSLHARPPQFTRAQWFAIQHISLNPPRCTIAMRAINNYRWRCKNQNTFLRTTFANVVNVCGNQSIRCPHNRTLNNCHRSRFRVPLLHCDLINPGAQNISNCTYADRPGRRFYVVACDNRDPRDSPRYPVVPVHLDTTI
PTMs - P12724 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y149 | Phosphorylation | Uniprot | |
| T158 | Phosphorylation | Uniprot | |
| T159 | Phosphorylation | Uniprot |
研究背景
Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content.
Secreted.
Note: Located in the matrix of eosinophil large specific granule, which are released following activation by an immune stimulus.
Interacts with bacterial lipopolysaccharide (LPS) and lipoteichoic acid (LTA). In vitro interacts with and insert into lipid bilayers composed of dioleoyl phosphatidylcholine and dioleoyl phosphatidylglycerol. In vitro, tends to form amyloid-like aggregates at pH 3, but not at pH 5, nor 7.
Belongs to the pancreatic ribonuclease family.
研究領域
· Human Diseases > Immune diseases > Asthma.
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