Elmo1 Antibody - #DF8539
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF8539, RRID:AB_2841743.
折りたたみ／展開
CED 12; Ced 12 homolog 1; Ced 12 homolog; CED-12; CED12; Ced12 homolog 1; Ced12 homolog; ELMO 1; ELMO-1; Elmo1; ELMO1_HUMAN; Engulfment and cell motility 1; Engulfment and cell motility protein 1; KIAA0281; MGC126406; Protein ced-12 homolog;
免疫原
- Q92556 ELMO1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPPPADIVKVAIEWPGAYPKLMEIDQKKPLSAIIKEVCDGWSLANHEYFALQHADSSNFYITEKNRNEIKNGTILRLTTSPAQNAQQLHERIQSSSMDAKLEALKDLASLSRDVTFAQEFINLDGISLLTQMVESGTERYQKLQKIMKPCFGDMLSFTLTAFVELMDHGIVSWDTFSVAFIKKIASFVNKSAIDISILQRSLAILESMVLNSHDLYQKVAQEITIGQLIPHLQGSDQEIQTYTIAVINALFLKAPDERRQEMANILAQKQLRSIILTHVIRAQRAINNEMAHQLYVLQVLTFNLLEDRMMTKMDPQDQAQRDIIFELRRIAFDAESEPNNSSGSMEKRKSMYTRDYKKLGFINHVNPAMDFTQTPPGMLALDNMLYFAKHHQDAYIRIVLENSSREDKHECPFGRSSIELTKMLCEILKVGELPSETCNDFHPMFFTHDRSFEEFFCICIQLLNKTWKEMRATSEDFNKVMQVVKEQVMRALTTKPSSLDQFKSKLQNLSYTEILKIRQSERMNQEDFQSRPILELKEKIQPEILELIKQQRLNRLVEGTCFRKLNARRRQDKFWYCRLSPNHKVLHYGDLEESPQGEVPHDSLQDKLPVADIKAVVTGKDCPHMKEKGALKQNKEVLELAFSILYDSNCQLNFIAPDKHEYCIWTDGLNALLGKDMMSDLTRNDLDTLLSMEIKLRLLDLENIQIPDAPPPIPKEPSNYDFVYDCN
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q92556 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K9 | Ubiquitination | Uniprot | |
| Y18 | Phosphorylation | P08631 (HCK) | Uniprot |
| K20 | Ubiquitination | Uniprot | |
| S31 | Phosphorylation | Uniprot | |
| Y48 | Phosphorylation | Uniprot | |
| K70 | Ubiquitination | Uniprot | |
| K100 | Acetylation | Uniprot | |
| K100 | Ubiquitination | Uniprot | |
| K105 | Acetylation | Uniprot | |
| K105 | Ubiquitination | Uniprot | |
| Y140 | Phosphorylation | Uniprot | |
| S196 | Phosphorylation | Uniprot | |
| Y216 | Phosphorylation | P08631 (HCK) | Uniprot |
| K269 | Ubiquitination | Uniprot | |
| K312 | Ubiquitination | Uniprot | |
| R328 | Methylation | Uniprot | |
| S341 | Phosphorylation | Uniprot | |
| S342 | Phosphorylation | Uniprot | |
| S344 | Phosphorylation | Uniprot | |
| K347 | Ubiquitination | Uniprot | |
| S350 | Phosphorylation | Uniprot | |
| Y352 | Phosphorylation | Uniprot | |
| Y356 | Phosphorylation | Uniprot | |
| Y395 | Phosphorylation | P08631 (HCK) | Uniprot |
| K408 | Acetylation | Uniprot | |
| K408 | Ubiquitination | Uniprot | |
| S416 | Phosphorylation | Uniprot | |
| S417 | Phosphorylation | Uniprot | |
| K422 | Acetylation | Uniprot | |
| K422 | Ubiquitination | Uniprot | |
| T466 | Phosphorylation | Uniprot | |
| K468 | Ubiquitination | Uniprot | |
| T473 | Phosphorylation | Uniprot | |
| K485 | Acetylation | Uniprot | |
| K485 | Ubiquitination | Uniprot | |
| K503 | Ubiquitination | Uniprot | |
| K505 | Ubiquitination | Uniprot | |
| Y511 | Phosphorylation | P08631 (HCK) | Uniprot |
| T512 | Phosphorylation | Uniprot | |
| K516 | Ubiquitination | Uniprot | |
| K537 | Ubiquitination | Uniprot | |
| K539 | Ubiquitination | Uniprot | |
| K549 | Ubiquitination | Uniprot | |
| Y576 | Phosphorylation | Uniprot | |
| K584 | Ubiquitination | Uniprot | |
| Y588 | Phosphorylation | Uniprot | |
| S594 | Phosphorylation | Uniprot | |
| K607 | Ubiquitination | Uniprot | |
| K620 | Ubiquitination | Uniprot | |
| K635 | Acetylation | Uniprot | |
| K695 | Ubiquitination | Uniprot | |
| S718 | Phosphorylation | Uniprot | |
| Y720 | Phosphorylation | P08631 (HCK) , P12931 (SRC) | Uniprot |
| Y724 | Phosphorylation | P12931 (SRC) | Uniprot |
研究背景
Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.
Phosphorylated by HCK.
Cytoplasm. Cell membrane.
Note: Translocation to plasma membrane seems to be mediated by DOCK1 and CRK.
Widely expressed, with a higher expression in the spleen and placenta.
Interacts with ADGRB1 (By similarity). Interacts directly with the SH3-domain of DOCK1 via its SH3-binding site. Part of a complex with DOCK1 and RAC1. Part of a complex with DOCK1 and CRK isoform CRK-II. Interacts with PLEKHG6. Interacts with HCK (via SH3 domain). Interacts with ADGRB3.
研究領域
· Human Diseases > Infectious diseases: Bacterial > Bacterial invasion of epithelial cells.
· Human Diseases > Infectious diseases: Bacterial > Shigellosis.
· Organismal Systems > Immune system > Chemokine signaling pathway. (View pathway)
Restrictive clause
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