HES2 Antibody - #DF8555
| 製品: | HES2 Antibody |
| カタログ: | DF8555 |
| タンパク質の説明: | Rabbit polyclonal antibody to HES2 |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat |
| 予測: | Rabbit |
| 分子量: | 18 kDa; 18kD(Calculated). |
| ユニプロット: | Q9Y543 |
| RRID: | AB_2841759 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF8555, RRID:AB_2841759.
折りたたみ／展開
;antibody;bHLHb40; Class B basic helix loop helix protein 40; Class B basic helix-loop-helix protein 40; Hairy and enhancer of split 2 (Drosophila); Hairy and enhancer of split 2; Hes2; HES2_HUMAN; Transcription factor HES 2; Transcription factor HES-2;
免疫原
Expressed in placenta, pancreatic cancer, colon cancer with RER, cervical cancer, and in head and neck tumors.
- Q9Y543 HES2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGLPRRAGDAAELRKSLKPLLEKRRRARINQSLSQLKGLILPLLGRENSNCSKLEKADVLEMTVRFLQELPASSWPTAAPLPCDSYREGYSACVARLARVLPACRVLEPAVSARLLEHLWRRAASATLDGGRAGDSSGPSAPAPAPASAPEPASAPVPSPPSPPCGPGLWRPW
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
研究背景
Transcriptional repressor of genes that require a bHLH protein for their transcription.
Nucleus.
Expressed in placenta, pancreatic cancer, colon cancer with RER, cervical cancer, and in head and neck tumors.
Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.
Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.
研究領域
· Human Diseases > Infectious diseases: Viral > Human papillomavirus infection.
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