PGE synthase Antibody - #DF8592

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製品: PGE synthase Antibody
カタログ: DF8592
タンパク質の説明: Rabbit polyclonal antibody to PGE synthase
アプリケーション: WB IHC
反応性: Human, Mouse, Rat
予測: Bovine, Horse, Sheep, Rabbit, Dog, Chicken
分子量: 17 kDa; 17kD(Calculated).
ユニプロット: O14684
RRID: AB_2841796

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 100ul $280 在庫あり
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MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:1000-3000, IHC 1:50-200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
予測:
Bovine(92%), Horse(91%), Sheep(92%), Rabbit(100%), Dog(83%), Chicken(91%)
クローナリティ:
Polyclonal
特異性:
PGE synthase Antibody detects endogenous levels of total PGE synthase.
RRID:
AB_2841796
引用形式: Affinity Biosciences Cat# DF8592, RRID:AB_2841796.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

Glutathione S transferase 1 like 1; MGC10317; MGST IV; MGST1 L1; MGST1 like 1; MGST1-L1; MGST1L1; MGSTIV; Microsomal glutathione S transferase 1 like 1; Microsomal glutathione S-transferase 1-like 1; Microsomal prostaglandin E synthase 1; Microsomal prostaglandin E synthase 1; mPGES 1; MPGES; mPGES-1; p53 induced apoptosis protein 12; p53 induced gene 12; p53 induced gene 12 protein; p53-induced gene 12 protein; PGES; PIG 12; PIG12; PP 102; PP 1294; PP102; PP1294; Prostaglandin E synthase; PTGES; PTGES_HUMAN; TP53I12; Tumor protein p53 inducible protein 12;

免疫原

免疫原:
Uniprot:

O14684(PTGES_HUMAN) >>Visit HPA database.

遺伝子(ID):
PTGES(9536)
タンパク質配列:
MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCRSDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGKLRAPIRSVTYTLAQLPCASMALQILWEAARHL

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Rabbit
100
Bovine
92
Sheep
92
Horse
91
Chicken
91
Dog
83
Zebrafish
67
Pig
0
Xenopus
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

研究背景

機能:

Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).

細胞の位置付け:

Membrane>Multi-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
サブユニット構造:

Homotrimer.

タンパク質ファミリー:

Belongs to the MAPEG family.

研究領域

· Metabolism > Lipid metabolism > Arachidonic acid metabolism.

· Metabolism > Global and overview maps > Metabolic pathways.

参考文献

1). Kiwi Root Extract Inhibits the Development of Endometriosis in Mice by Downregulating Inflammatory Factors. Evidence-based Complementary and Alternative Medicine, 2021 (PubMed: 33574880)

Application: WB    Species: Mice    Sample: endometriotic tissue

Figure 6 The expression of COX-1, COX-2, and EP2 mRNA and the expression of COX-1, COX-2, mPGEs, EP2, and PGE2 protein in endometriotic tissue of different groups. (a) The relative expression level of COX-1, COX-2, PGE2, and EP2 protein was detected by immunohistochemical staining (×200); the scale bar represents 50 microns. (b) The relative expression level of COX-1, COX-2, and mPGEs protein was detected by western blot. Data are expressed as mean ± standard deviation from triplicate experiments. (c) The relative expression level of COX-1, COX-2, and EP2 mRNA was detected by RT-PCR (∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001, and ∗∗∗∗P < 0.0001).

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