Sarcoglycan beta Antibody - #DF8605
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF8605, RRID:AB_2841809.
折りたたみ／展開
43 kDa dystrophin associated glycoprotein; 43 kDa dystrophin-associated glycoprotein; 43DAG; A3b; Beta SG; Beta-sarcoglycan; Beta-SG; dystrophin-associated glycoprotein, 43-kD; LGMD2E; Limb girdle muscular dystrophy 2E (non linked families); Sarcoglycan beta; sarcoglycan, beta (43kDa dystrophin-associated glycoprotein); SGC; SGCB; SGCB_HUMAN;
免疫原
Highest expression in heart and skeletal muscle. Low expression in brain, kidney, placenta, pancreas and lung. High expression in fetal brain. Also found in fetal lung, kidney and liver.
- Q16585 SGCB_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAAAAAAAEQQSSNGPVKKSMREKAVERRSVNKEHNSNFKAGYIPIDEDRLHKTGLRGRKGNLAICVIILLFILAVINLIITLVIWAVIRIGPNGCDSMEFHESGLLRFKQVSDMGVIHPLYKSTVGGRRNENLVITGNNQPIVFQQGTTKLSVENNKTSITSDIGMQFFDPRTQNILFSTDYETHEFHLPSGVKSLNVQKASTERITSNATSDLNIKVDGRAIVRGNEGVFIMGKTIEFHMGGNMELKAENSIILNGSVMVSTTRLPSSSSGDQLGSGDWVRYKLCMCADGTLFKVQVTSQNMGCQISDNPCGNTH
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q16585 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K34 | Ubiquitination | Uniprot | |
| K41 | Ubiquitination | Uniprot | |
| Y44 | Phosphorylation | Uniprot | |
| K111 | Ubiquitination | Uniprot | |
| K124 | Ubiquitination | Uniprot | |
| K152 | Ubiquitination | Uniprot | |
| N158 | N-Glycosylation | Uniprot | |
| K196 | Ubiquitination | Uniprot | |
| K202 | Ubiquitination | Uniprot | |
| N211 | N-Glycosylation | Uniprot | |
| K219 | Ubiquitination | Uniprot | |
| T266 | Phosphorylation | Uniprot | |
| K286 | Ubiquitination | Uniprot |
研究背景
Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
Disulfide bonds are present.
Cell membrane>Sarcolemma>Single-pass type II membrane protein. Cytoplasm>Cytoskeleton.
Highest expression in heart and skeletal muscle. Low expression in brain, kidney, placenta, pancreas and lung. High expression in fetal brain. Also found in fetal lung, kidney and liver.
Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans (By similarity).
Belongs to the sarcoglycan beta/delta/gamma/zeta family.
研究領域
· Human Diseases > Cardiovascular diseases > Hypertrophic cardiomyopathy (HCM).
· Human Diseases > Cardiovascular diseases > Arrhythmogenic right ventricular cardiomyopathy (ARVC).
· Human Diseases > Cardiovascular diseases > Dilated cardiomyopathy (DCM).
· Human Diseases > Cardiovascular diseases > Viral myocarditis.
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