SEMA4C Antibody - #DF8612
| 製品: | SEMA4C Antibody |
| カタログ: | DF8612 |
| タンパク質の説明: | Rabbit polyclonal antibody to SEMA4C |
| アプリケーション: | WB |
| 反応性: | Human |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit |
| 分子量: | 92 kDa; 93kD(Calculated). |
| ユニプロット: | Q9C0C4 |
| RRID: | AB_2841816 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF8612, RRID:AB_2841816.
折りたたみ／展開
KIAA1739; M-SEMA-F; S4c; SEM4C_HUMAN; Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C; SEMA4C; SEMACL1; SEMAF; SEMAI; Semaphorin-4C; UNQ5855/PRO34487;
免疫原
- Q9C0C4 SEM4C_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAPHWAVWLLAARLWGLGIGAEVWWNLVPRKTVSSGELATVVRRFSQTGIQDFLTLTLTEPTGLLYVGAREALFAFSMEALELQGAISWEAPVEKKTECIQKGKNNQTECFNFIRFLQPYNASHLYVCGTYAFQPKCTYVNMLTFTLEHGEFEDGKGKCPYDPAKGHAGLLVDGELYSATLNNFLGTEPIILRNMGPHHSMKTEYLAFWLNEPHFVGSAYVPESVGSFTGDDDKVYFFFRERAVESDCYAEQVVARVARVCKGDMGGARTLQRKWTTFLKARLACSAPNWQLYFNQLQAMHTLQDTSWHNTTFFGVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWDRYTDPVPSPRPGSCINNWHRRHGYTSSLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTNFTHLVADRVTGLDGATYTVLFIGTGDGWLLKAVSLGPWVHLIEELQLFDQEPMRSLVLSQSKKLLFAGSRSQLVQLPVADCMKYRSCADCVLARDPYCAWSVNTSRCVAVGGHSGSLLIQHVMTSDTSGICNLRGSKKVRPTPKNITVVAGTDLVLPCHLSSNLAHARWTFGGRDLPAEQPGSFLYDARLQALVVMAAQPRHAGAYHCFSEEQGARLAAEGYLVAVVAGPSVTLEARAPLENLGLVWLAVVALGAVCLVLLLLVLSLRRRLREELEKGAKATERTLVYPLELPKEPTSPPFRPCPEPDEKLWDPVGYYYSDGSLKIVPGHARCQPGGGPPSPPPGIPGQPLPSPTRLHLGGGRNSNANGYVRLQLGGEDRGGLGHPLPELADELRRKLQQRQPLPDSNPEESSV
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9C0C4 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y249 | Phosphorylation | Uniprot | |
| K481 | Ubiquitination | Uniprot | |
| S488 | Phosphorylation | Uniprot | |
| T704 | Phosphorylation | Uniprot | |
| Y707 | Phosphorylation | Uniprot | |
| K713 | Ubiquitination | Uniprot | |
| S717 | Phosphorylation | Uniprot | |
| K729 | Ubiquitination | Uniprot | |
| Y736 | Phosphorylation | Uniprot | |
| Y737 | Phosphorylation | Uniprot | |
| S739 | Phosphorylation | Uniprot | |
| S742 | Phosphorylation | Uniprot | |
| K744 | Ubiquitination | Uniprot | |
| S760 | Phosphorylation | Uniprot | |
| S772 | Phosphorylation | Uniprot | |
| Y789 | Phosphorylation | Uniprot | |
| S832 | Phosphorylation | Uniprot |
研究背景
Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration (By similarity). Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade.
Cell junction>Synapse>Postsynaptic density membrane>Single-pass type I membrane protein. Cytoplasmic vesicle>Secretory vesicle>Synaptic vesicle membrane>Single-pass type I membrane protein.
Interacts (via the PDZ-binding motif) with GIPC (via the PDZ domain) (By similarity). Interacts with NCDN (By similarity). Interacts (via the PDZ-binding motif) with DLG4. Interacts with PLXNB2 (By similarity).
Belongs to the semaphorin family.
研究領域
· Organismal Systems > Development > Axon guidance. (View pathway)
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