TASK-1 Antibody - #DF8620
| 製品: | TASK-1 Antibody |
| カタログ: | DF8620 |
| タンパク質の説明: | Rabbit polyclonal antibody to TASK-1 |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| 分子量: | 43 kDa; 44kD(Calculated). |
| ユニプロット: | O14649 |
| RRID: | AB_2841824 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF8620, RRID:AB_2841824.
折りたたみ／展開
Acid sensitive potassium channel protein TASK 1; Acid sensitive potassium channel protein TASK; Acid-sensitive potassium channel protein TASK-1; Cardiac two pore background K(+) channel; cTBAK 1; K2p3.1; KCNK3; KCNK3_HUMAN; OAT1; Potassium channel subfamily K member 3; potassium channel, subfamily K, member 3; Potassium inwardly rectifying channel subfamily K member 3; PPH4; rTASK; TASK 1; TASK; TBAK1; TWIK related acid sensitive K+ channel; TWIK-related acid-sensitive K(+) channel 1; Two P domain potassium channel; Two pore K(+) channel KT3.; Two pore K(+) channel KT3.1; Two pore potassium channel KT3.1;
免疫原
Widespread expression in adult. Strongest expression in pancreas and placenta. Lower expression in brain, lung, prostate, heart, kidney, uterus, small intestine and colon.
- O14649 KCNK3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MKRQNVRTLALIVCTFTYLLVGAAVFDALESEPELIERQRLELRQQELRARYNLSQGGYEELERVVLRLKPHKAGVQWRFAGSFYFAITVITTIGYGHAAPSTDGGKVFCMFYALLGIPLTLVMFQSLGERINTLVRYLLHRAKKGLGMRRADVSMANMVLIGFFSCISTLCIGAAAFSHYEHWTFFQAYYYCFITLTTIGFGDYVALQKDQALQTQPQYVAFSFVYILTGLTVIGAFLNLVVLRFMTMNAEDEKRDAEHRALLTRNGQAGGGGGGGSAHTTDTASSTAAAGGGGFRNVYAEVLHFQSMCSCLWYKSREKLQYSIPMIIPRDLSTSDTCVEQSHSSPGGGGRYSDTPSRRCLCSGAPRSAISSVSTGLHSLSTFRGLMKRRSSV
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O14649 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| R64 | Methylation | Uniprot | |
| Y113 | Phosphorylation | Uniprot | |
| Y300 | Phosphorylation | Uniprot | |
| Y315 | Phosphorylation | Uniprot | |
| Y323 | Phosphorylation | Uniprot | |
| T335 | Phosphorylation | Uniprot | |
| S336 | Phosphorylation | Q13464 (ROCK1) | Uniprot |
| S358 | Phosphorylation | Uniprot | |
| S364 | Phosphorylation | Uniprot | |
| S369 | Phosphorylation | Uniprot | |
| T383 | Phosphorylation | Q02156 (PRKCE) | Uniprot |
| S392 | Phosphorylation | Uniprot | |
| S393 | Phosphorylation | P51812 (RPS6KA3) , Q13464 (ROCK1) , P17612 (PRKACA) | Uniprot |
研究背景
pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward.
Cell membrane>Multi-pass membrane protein.
Widespread expression in adult. Strongest expression in pancreas and placenta. Lower expression in brain, lung, prostate, heart, kidney, uterus, small intestine and colon.
Homodimer (Probable). Heterodimer with KCNK1.
Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
研究領域
· Organismal Systems > Endocrine system > Aldosterone synthesis and secretion.
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