CLK4 Antibody - #DF8645
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF8645, RRID:AB_2841849.
折りたたみ／展開
AI987988; C85119; CDC like kinase 4; CDC-like kinase 4; CLK4; CLK4_HUMAN; DKFZp686A20267; Dual specificity protein kinase CLK4; OTTMUSP00000005756;; OTTMUSP00000005757; OTTMUSP00000041113; Protein serine threonine kinase Clk4; RP23-9N7.1;
免疫原
- Q9HAZ1 CLK4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9HAZ1 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S17 | Phosphorylation | Uniprot | |
| S33 | Phosphorylation | Uniprot | |
| S35 | Phosphorylation | Uniprot | |
| Y80 | Phosphorylation | Uniprot | |
| S95 | Phosphorylation | Uniprot | |
| S108 | Phosphorylation | Uniprot | |
| S111 | Phosphorylation | Uniprot | |
| S112 | Phosphorylation | Uniprot | |
| S122 | Phosphorylation | Uniprot | |
| S123 | Phosphorylation | Uniprot | |
| S126 | Phosphorylation | Uniprot | |
| S128 | Phosphorylation | Uniprot | |
| S136 | Phosphorylation | Uniprot | |
| S138 | Phosphorylation | Uniprot | |
| K189 | Sumoylation | Uniprot | |
| K189 | Ubiquitination | Uniprot | |
| K296 | Ubiquitination | Uniprot | |
| K302 | Ubiquitination | Uniprot | |
| K315 | Ubiquitination | Uniprot | |
| S326 | Phosphorylation | Uniprot | |
| T328 | Phosphorylation | Uniprot | |
| S335 | Phosphorylation | Uniprot | |
| T336 | Phosphorylation | Uniprot | |
| S339 | Phosphorylation | Uniprot | |
| T340 | Phosphorylation | Uniprot | |
| Y343 | Phosphorylation | Uniprot | |
| K479 | Ubiquitination | Uniprot |
研究背景
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.
Autophosphorylates on all three types of residues.
Nucleus.
Expressed in liver, kidney, heart, muscle, brain and endothelial cells.
Interacts with UBL5.
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.
Restrictive clause
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For Research Use Only.
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