FAF1 Antibody - #DF8655
| 製品: | FAF1 Antibody |
| カタログ: | DF8655 |
| タンパク質の説明: | Rabbit polyclonal antibody to FAF1 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Zebrafish, Bovine, Horse, Sheep, Dog, Chicken |
| 分子量: | 73 kDa; 74kD(Calculated). |
| ユニプロット: | Q9UNN5 |
| RRID: | AB_2841859 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF8655, RRID:AB_2841859.
折りたたみ／展開
CGI 03; FAF1; FAF1 protein; FAF1_HUMAN; Fas (TNFRSF6) associated factor 1; FAS associated factor 1; Fas associated protein factor 1; FAS-associated factor 1; FLJ37524; hFAF1; HFAF1s; Protein FAF1; TNFRSF6 associated factor 1; UBX domain protein 3A; UBX domain-containing protein 12; UBX domain-containing protein 3A; UBXD12; UBXN3A;
免疫原
Most abundant in testis, slightly less abundant in skeletal muscle and heart, followed by prostate, thymus, ovary, small intestine, and colon. Not detected in the peripheral blood leukocytes.
- Q9UNN5 FAF1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MASNMDREMILADFQACTGIENIDEAITLLEQNNWDLVAAINGVIPQENGILQSEYGGETIPGPAFNPASHPASAPTSSSSSAFRPVMPSRQIVERQPRMLDFRVEYRDRNVDVVLEDTCTVGEIKQILENELQIPVSKMLLKGWKTGDVEDSTVLKSLHLPKNNSLYVLTPDLPPPSSSSHAGALQESLNQNFMLIITHREVQREYNLNFSGSSTIQEVKRNVYDLTSIPVRHQLWEGWPTSATDDSMCLAESGLSYPCHRLTVGRRSSPAQTREQSEEQITDVHMVSDSDGDDFEDATEFGVDDGEVFGMASSALRKSPMMPENAENEGDALLQFTAEFSSRYGDCHPVFFIGSLEAAFQEAFYVKARDRKLLAIYLHHDESVLTNVFCSQMLCAESIVSYLSQNFITWAWDLTKDSNRARFLTMCNRHFGSVVAQTIRTQKTDQFPLFLIIMGKRSSNEVLNVIQGNTTVDELMMRLMAAMEIFTAQQQEDIKDEDEREARENVKREQDEAYRLSLEADRAKREAHEREMAEQFRLEQIRKEQEEEREAIRLSLEQALPPEPKEENAEPVSKLRIRTPSGEFLERRFLASNKLQIVFDFVASKGFPWDEYKLLSTFPRRDVTQLDPNKSLLEVKLFPQETLFLEAKE
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9UNN5 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K139 | Ubiquitination | Uniprot | |
| K143 | Ubiquitination | Uniprot | |
| K146 | Acetylation | Uniprot | |
| K146 | Ubiquitination | Uniprot | |
| K157 | Acetylation | Uniprot | |
| K157 | Ubiquitination | Uniprot | |
| K163 | Ubiquitination | Uniprot | |
| K221 | Ubiquitination | Uniprot | |
| Y225 | Phosphorylation | Uniprot | |
| T264 | Phosphorylation | Uniprot | |
| S269 | Phosphorylation | Uniprot | |
| S270 | Phosphorylation | Uniprot | |
| T274 | Phosphorylation | Uniprot | |
| S289 | Phosphorylation | P68400 (CSNK2A1) , O14965 (AURKA) | Uniprot |
| S291 | Phosphorylation | O14965 (AURKA) , P68400 (CSNK2A1) | Uniprot |
| K319 | Ubiquitination | Uniprot | |
| S320 | Phosphorylation | Uniprot | |
| S342 | Phosphorylation | Uniprot | |
| S343 | Phosphorylation | Uniprot | |
| K444 | Ubiquitination | Uniprot | |
| K457 | Ubiquitination | Uniprot | |
| K508 | Sumoylation | Uniprot | |
| K544 | Ubiquitination | Uniprot | |
| S556 | Phosphorylation | Uniprot | |
| K566 | Ubiquitination | Uniprot | |
| K575 | Ubiquitination | Uniprot | |
| T580 | Phosphorylation | Uniprot | |
| S582 | Phosphorylation | Uniprot | |
| K631 | Ubiquitination | Uniprot | |
| K637 | Ubiquitination | Uniprot |
研究背景
Ubiquitin-binding protein. Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation. Potentiates but cannot initiate FAS-induced apoptosis (By similarity).
Nucleus.
Most abundant in testis, slightly less abundant in skeletal muscle and heart, followed by prostate, thymus, ovary, small intestine, and colon. Not detected in the peripheral blood leukocytes.
Interacts with CDT1 and ATPase VCP/p97. Interacts (via UBA domain) with FAS (via death domain). Interacts (via UBA domain) with NLRP12 (via DAPIN/PYRIN domain).
研究領域
· Cellular Processes > Cell growth and death > Necroptosis. (View pathway)
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