製品: GPR105 Antibody
カタログ: DF8662
タンパク質の説明: Rabbit polyclonal antibody to GPR105
アプリケーション: WB IHC IF/ICC
反応性: Human, Mouse, Rat
予測: Pig, Rabbit, Dog
分子量: 38 kDa; 39kD(Calculated).
ユニプロット: Q15391
RRID: AB_2841866

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製品説明

ソース:
Rabbit
アプリケーション:
WB 1:1000-3000, IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
予測:
Pig(83%), Rabbit(83%), Dog(82%)
クローナリティ:
Polyclonal
特異性:
GPR105 Antibody detects endogenous levels of total GPR105.
RRID:
AB_2841866
引用形式: Affinity Biosciences Cat# DF8662, RRID:AB_2841866.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ/展開

A330108O13Rik; G protein coupled receptor for UDP-glucose; G protein-coupled receptor 105; G protein-coupled receptor VTR 15-20; G-protein coupled receptor 105; GPR105; KIAA0001; P2RY14; P2Y purinoceptor 14; P2Y(14) receptor; P2Y14; P2Y14 receptor; P2Y14_HUMAN; Purinergic receptor P2Y G protein coupled 14; Similar to TYPE-1 Angiotensin II receptor; UDP-glucose receptor;

免疫原

免疫原:
Uniprot:
遺伝子(ID):
発現特異性:
Q15391 P2Y14_HUMAN:

Highest expression in the placenta, adipose tissue, stomach and intestine, intermediate levels in the brain, spleen, lung and heart, lowest levels in the kidney.

タンパク質配列:
MINSTSTQPPDESCSQNLLITQQIIPVLYCMVFIAGILLNGVSGWIFFYVPSSKSFIIYLKNIVIADFVMSLTFPFKILGDSGLGPWQLNVFVCRVSAVLFYVNMYVSIVFFGLISFDRYYKIVKPLWTSFIQSVSYSKLLSVIVWMLMLLLAVPNIILTNQSVREVTQIKCIELKSELGRKWHKASNYIFVAIFWIVFLLLIVFYTAITKKIFKSHLKSSRNSTSVKKKSSRNIFSIVFVFFVCFVPYHIARIPYTKSQTEAHYSCQSKEILRYMKEFTLLLSAANVCLDPIIYFFLCQPFREILCKKLHIPLKAQNDLDISRIKRGNTTLESTDTL

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Rabbit
83
Pig
83
Dog
82
Bovine
75
Sheep
75
Chicken
73
Horse
67
Xenopus
58
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q15391 基板として

Site PTM Type Enzyme
S269 Phosphorylation
S323 Phosphorylation
T337 Phosphorylation

研究背景

機能:

Receptor for UDP-glucose and other UDP-sugar coupled to G-proteins. Not activated by ATP, ADP, UTP or ATP.

細胞の位置付け:

Cell membrane>Multi-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Highest expression in the placenta, adipose tissue, stomach and intestine, intermediate levels in the brain, spleen, lung and heart, lowest levels in the kidney.

タンパク質ファミリー:

Belongs to the G-protein coupled receptor 1 family.

研究領域

· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.

参考文献

1). Reyanning mixture inhibits M1 macrophage polarization through the glycogen synthesis pathway to improve lipopolysaccharide-induced acute lung injury. Journal of ethnopharmacology, 2024 (PubMed: 38508433) [IF=5.4]

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