HMG14 Antibody - #DF8777
| 製品: | HMG14 Antibody |
| カタログ: | DF8777 |
| タンパク質の説明: | Rabbit polyclonal antibody to HMG14 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human |
| 予測: | Pig, Bovine, Horse, Dog, Chicken, Xenopus |
| 分子量: | 10 kDa; 11kD(Calculated). |
| ユニプロット: | P05114 |
| RRID: | AB_2841980 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF8777, RRID:AB_2841980.
折りたたみ／展開
FLJ27265; FLJ31471; High mobility group (nonhistone chromosomal) protein 14; High mobility group nucleosome binding 1; High mobility group nucleosome binding domain 1; High mobility group nucleosome binding domain containing protein 1; High mobility group nucleosome-binding domain-containing protein 1; High mobility group protein 14; HMG 14; HMG14; HMGN 1; HMGN1; HMGN1_HUMAN; MGC104230; MGC117425; Non-histone chromosomal protein HMG-14; Nonhistone chromosomal protein HMG 14; Nonhistone chromosomal protein HMG14;
免疫原
- P05114 HMGN1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPKRKVSSAEGAAKEEPKRRSARLSAKPPAKVEAKPKKAAAKDKSSDKKVQTKGKRGAKGKQAEVANQETKEDLPAENGETKTEESPASDEAGEKEAKSD
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P05114 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K3 | Acetylation | Uniprot | |
| K5 | Acetylation | Uniprot | |
| K5 | Methylation | Uniprot | |
| K5 | Ubiquitination | Uniprot | |
| S7 | Phosphorylation | P68400 (CSNK2A1) , O75676 (RPS6KA4) , P17612 (PRKACA) , P51812 (RPS6KA3) , O75582 (RPS6KA5) , P17252 (PRKCA) | Uniprot |
| S8 | Phosphorylation | P68400 (CSNK2A1) | Uniprot |
| K14 | Acetylation | Uniprot | |
| K14 | Ubiquitination | Uniprot | |
| K18 | Acetylation | Uniprot | |
| S21 | Phosphorylation | P51812 (RPS6KA3) , P17612 (PRKACA) , P17252 (PRKCA) | Uniprot |
| S25 | Phosphorylation | P17252 (PRKCA) , P51812 (RPS6KA3) , P17612 (PRKACA) | Uniprot |
| K27 | Acetylation | Uniprot | |
| K27 | Ubiquitination | Uniprot | |
| K31 | Acetylation | Uniprot | |
| K31 | Ubiquitination | Uniprot | |
| K38 | Acetylation | Uniprot | |
| K42 | Acetylation | Uniprot | |
| K48 | Acetylation | Uniprot | |
| K53 | Acetylation | Uniprot | |
| K55 | Acetylation | Uniprot | |
| K59 | Acetylation | Uniprot | |
| K61 | Acetylation | Uniprot | |
| K61 | Ubiquitination | Uniprot | |
| T70 | Phosphorylation | Uniprot | |
| K71 | Ubiquitination | Uniprot | |
| T81 | Phosphorylation | Uniprot | |
| K82 | Acetylation | Uniprot | |
| K82 | Ubiquitination | Uniprot | |
| T83 | Phosphorylation | Uniprot | |
| S86 | Phosphorylation | P68400 (CSNK2A1) | Uniprot |
| S89 | Phosphorylation | P68400 (CSNK2A1) | Uniprot |
| K95 | Ubiquitination | Uniprot | |
| K98 | Ubiquitination | Uniprot | |
| S99 | Phosphorylation | P68400 (CSNK2A1) | Uniprot |
研究背景
Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity).
Phosphorylation on Ser-21 and Ser-25 weakens binding to nucleosomes and increases the rate of H3 phosphorylation (By similarity). Phosphorylation favors cytoplasmic localization.
Nucleus. Cytoplasm.
Note: Cytoplasmic enrichment upon phosphorylation. The RNA edited version localizes to the nucleus.
Belongs to the HMGN family.
研究領域
· Human Diseases > Infectious diseases: Viral > Herpes simplex infection.
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