Adrenergic Receptor alpha -1B Antibody - #DF8798
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| 製品: | Adrenergic Receptor alpha -1B Antibody |
| カタログ: | DF8798 |
| タンパク質の説明: | Rabbit polyclonal antibody to Adrenergic Receptor alpha -1B |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse, Rat, Monkey |
| 予測: | Rabbit, Dog, Chicken |
| 分子量: | 56 kDa; 57kD(Calculated). |
| ユニプロット: | P35368 |
| RRID: | AB_2841996 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF8798, RRID:AB_2841996.
折りたたみ／展開
ADA1B_HUMAN; ADRA 1; Adra 1b; ADRA1; ADRA1B; Adrenergic alpha 1B receptor; Adrenergic receptor alpha 1b; Adrenoceptor alpha 1B; Alpha 1 adrenergic receptor; Alpha 1B adrenoceptor; Alpha 1B adrenoreceptor; Alpha-1B adrenergic receptor; Alpha-1B adrenoceptor; Alpha-1B adrenoreceptor; Alpha1 adrenergic receptor; Alpha1B adrenergic receptor; Alpha1BAR;
免疫原
- P35368 ADA1B_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MNPDLDTGHNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFVRILGCQCRGRGRRRRRRRRRLGGCAYTYRPWTRGGSLERSQSRKDSLDDSGSCLSGSQRTLPSASPSPGYLGRGAPPPVELCAFPEWKAPGALLSLPAPEPPGRRGRHDSGPLFTFKLLTEPESPGTDGGASNGGCEAAADVANGQPGFKSNMPLAPGQF
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P35368 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y144 | Phosphorylation | Uniprot | |
| Y149 | Phosphorylation | Uniprot | |
| Y153 | Phosphorylation | Uniprot | |
| R389 | Methylation | Uniprot | |
| R393 | Methylation | Uniprot | |
| S396 | Phosphorylation | P17252 (PRKCA) | Uniprot |
| R399 | Methylation | Uniprot | |
| S402 | Phosphorylation | P17252 (PRKCA) | Uniprot |
| R403 | Methylation | Uniprot | |
| S406 | Phosphorylation | P17252 (PRKCA) | Uniprot |
| S410 | Phosphorylation | P17252 (PRKCA) | Uniprot |
| S412 | Phosphorylation | P17252 (PRKCA) | Uniprot |
| S417 | Phosphorylation | Uniprot | |
| S470 | Phosphorylation | Uniprot |
研究背景
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.
Nucleus membrane>Multi-pass membrane protein. Cell membrane>Multi-pass membrane protein. Cytoplasm. Membrane>Caveola.
Note: Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes.
Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes. Interacts with CAVIN4.
Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1B sub-subfamily.
研究領域
· Environmental Information Processing > Signal transduction > Calcium signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > cGMP-PKG signaling pathway. (View pathway)
· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.
· Organismal Systems > Circulatory system > Adrenergic signaling in cardiomyocytes. (View pathway)
· Organismal Systems > Circulatory system > Vascular smooth muscle contraction. (View pathway)
· Organismal Systems > Digestive system > Salivary secretion.
参考文献
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