MSX1/2 Antibody - #DF8799
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF8799, RRID:AB_2841997.
折りたたみ／展開
AA675338; AI324650; Homeobox 7; Homeobox protein Hox-7; Homeobox protein MSX 1; Homeobox protein MSX-1; Homeobox protein MSX1; Homeobox, msh like 1; Homeobox, msh-like 1; HOX 7; Hox 7.1; Hox-7; HOX7; Hox7.1; HYD 1; HYD1; msh (Drosophila) homeo box homolog 1 (formerly homeo box 7); Msh; msh homeo box 1; msh homeo box homolog 1; Msh homeobox 1; Msh homeobox 1 like protein; Msh homeobox 1-like protein; msh homeobox homolog 1 (Drosophila); msh homeobox homolog 1; MSH, Drosophila, Homolog of, 1; MSX 1; MSX1; MSX1_HUMAN; Muscle segment homeobox; Muscle segment homeobox, Drosophila, Homolog of, 1; OFC5; OTTHUMP00000115387; STHAG1; CRS 2; CRS2; FPP; Homeo box msh like 2; Homeobox protein Hox-8; Homeobox protein MSX 2; Homeobox protein MSX-2; Homeobox protein MSX2; Hox 8; Hox8; MSH; Msh homeo box 2; Msh homeo box homolog; Msh homeo box homolog 2; Msh homeobox 2; Msh homeobox homolog 2; Msx 2; MSX2; MSX2_HUMAN; Parietal foramina 1; PFM 1; PFM; PFM1;
免疫原
- P28360 MSX1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAPAADMTSLPLGVKVEDSAFGKPAGGGAGQAPSAAAATAAAMGADEEGAKPKVSPSLLPFSVEALMADHRKPGAKESALAPSEGVQAAGGSAQPLGVPPGSLGAPDAPSSPRPLGHFSVGGLLKLPEDALVKAESPEKPERTPWMQSPRFSPPPARRLSPPACTLRKHKTNRKPRTPFTTAQLLALERKFRQKQYLSIAERAEFSSSLSLTETQVKIWFQNRRAKAKRLQEAELEKLKMAAKPMLPPAAFGLSFPLGGPAAVAAAAGASLYGASGPFQRAALPVAPVGLYTAHVGYSMYHLT
- P35548 MSX2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MASPSKGNDLFSPDEEGPAVVAGPGPGPGGAEGAAEERRVKVSSLPFSVEALMSDKKPPKEASPLPAESASAGATLRPLLLSGHGAREAHSPGPLVKPFETASVKSENSEDGAAWMQEPGRYSPPPRHMSPTTCTLRKHKTNRKPRTPFTTSQLLALERKFRQKQYLSIAERAEFSSSLNLTETQVKIWFQNRRAKAKRLQEAELEKLKMAAKPMLPSSFSLPFPISSPLQAASIYGASYPFHRPVLPIPPVGLYATPVGYGMYHLS
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P28360/P35548 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S63 | Phosphorylation | Uniprot | |
| S91 | Phosphorylation | Uniprot | |
| Y122 | Phosphorylation | Uniprot | |
| S123 | Phosphorylation | Uniprot | |
| S130 | Phosphorylation | Uniprot | |
| T135 | Phosphorylation | P05771 (PRKCB) | Uniprot |
| T141 | Phosphorylation | P05771 (PRKCB) | Uniprot |
| K160 | Acetylation | Uniprot | |
| K164 | Acetylation | Uniprot | |
| K207 | Ubiquitination | Uniprot |
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S136 | Phosphorylation | Uniprot | |
| S148 | Phosphorylation | Uniprot | |
| S152 | Phosphorylation | Uniprot | |
| S160 | Phosphorylation | Uniprot | |
| T180 | Phosphorylation | Uniprot | |
| K237 | Ubiquitination | Uniprot |
研究背景
Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis. Expression in the developing nail bed mesenchyme is important for nail plate thickness and integrity.
Sumoylated by PIAS1, desumoylated by SENP1.
Nucleus.
Expressed in the developing nail bed mesenchyme.
Belongs to the Msh homeobox family.
Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter.
Nucleus.
Interacts with MINT (By similarity). Interacts with XRCC6 (Ku70) and XRCC5 (Ku80).
Belongs to the Msh homeobox family.
研究領域
· Human Diseases > Infectious diseases: Viral > HTLV-I infection.
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