MAP3K9 Antibody - #DF8808
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| 製品: | MAP3K9 Antibody |
| カタログ: | DF8808 |
| タンパク質の説明: | Rabbit polyclonal antibody to MAP3K9 |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 121 kDa; 122kD(Calculated). |
| ユニプロット: | P80192 |
| RRID: | AB_2842005 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF8808, RRID:AB_2842005.
折りたたみ／展開
MEKK10; MEKK9; Mitogen activated protein kinase kinase kinase 10; Mitogen activated protein kinase kinase kinase 9; Mixed lineage kinase 1 (tyr and ser/thr specificity); Mixed lineage kinase 2; MKN28 derived nonreceptor_type serine/threonine kinase; MKN28 kinase; MLK1; MLK2; MST; PRKE1; Protein kinase MST;
免疫原
Expressed in epithelial tumor cell lines of colonic, breast and esophageal origin.
- P80192 M3K9_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P80192 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y110 | Phosphorylation | Uniprot | |
| K193 | Ubiquitination | Uniprot | |
| T304 | Phosphorylation | P80192 (MAP3K9) | Uniprot |
| T305 | Phosphorylation | P80192 (MAP3K9) | Uniprot |
| S308 | Phosphorylation | P80192 (MAP3K9) | Uniprot |
| T312 | Phosphorylation | P80192 (MAP3K9) | Uniprot |
| T452 | Phosphorylation | Uniprot | |
| S519 | Phosphorylation | Uniprot | |
| S533 | Phosphorylation | Uniprot | |
| T535 | Phosphorylation | Uniprot | |
| S547 | Phosphorylation | Uniprot | |
| S548 | Phosphorylation | Uniprot | |
| S552 | Phosphorylation | Uniprot | |
| T554 | Phosphorylation | Uniprot | |
| T565 | Phosphorylation | Uniprot | |
| K594 | Acetylation | Uniprot | |
| K595 | Acetylation | Uniprot | |
| K607 | Acetylation | Uniprot | |
| S616 | Phosphorylation | Uniprot | |
| S652 | Phosphorylation | Uniprot | |
| K658 | Ubiquitination | Uniprot | |
| S693 | Phosphorylation | Uniprot | |
| S695 | Phosphorylation | Uniprot | |
| S807 | Phosphorylation | Uniprot | |
| T808 | Phosphorylation | Uniprot | |
| S809 | Phosphorylation | Uniprot | |
| S812 | Phosphorylation | Uniprot | |
| T915 | Phosphorylation | Uniprot | |
| S917 | Phosphorylation | Uniprot | |
| S938 | Phosphorylation | Uniprot | |
| T948 | Phosphorylation | Uniprot |
PTMs - P80192 酵素として
研究背景
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.
Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Thr-312 is likely to be the main autophosphorylation site. Autophosphorylation also occurs on Thr-304 and Ser-308.
Expressed in epithelial tumor cell lines of colonic, breast and esophageal origin.
Homodimer.
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
参考文献
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