ZBTB17 Antibody - #DF8822
| 製品: | ZBTB17 Antibody |
| カタログ: | DF8822 |
| タンパク質の説明: | Rabbit polyclonal antibody to ZBTB17 |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Horse, Rabbit, Dog |
| 分子量: | 88 kDa; 88kD(Calculated). |
| ユニプロット: | Q13105 |
| RRID: | AB_2842019 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF8822, RRID:AB_2842019.
折りたたみ／展開
Miz-1; Myc-interacting zinc finger protein 1; Myc-interacting zinc finger protein; ZBT17; ZBT17_HUMAN; Zbtb17; Zinc finger and BTB domain containing protein 17; Zinc finger and BTB domain-containing protein 17; Zinc finger protein 151; Zinc finger protein 60; ZNF151; ZNF60;
免疫原
- Q13105 ZBT17_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDFPQHSQHVLEQLNQQRQLGLLCDCTFVVDGVHFKAHKAVLAACSEYFKMLFVDQKDVVHLDISNAAGLGQVLEFMYTAKLSLSPENVDDVLAVATFLQMQDIITACHALKSLAEPATSPGGNAEALATEGGDKRAKEEKVATSTLSRLEQAGRSTPIGPSRDLKEERGGQAQSAASGAEQTEKADAPREPPPVELKPDPTSGMAAAEAEAALSESSEQEMEVEPARKGEEEQKEQEEQEEEGAGPAEVKEEGSQLENGEAPEENENEESAGTDSGQELGSEARGLRSGTYGDRTESKAYGSVIHKCEDCGKEFTHTGNFKRHIRIHTGEKPFSCRECSKAFSDPAACKAHEKTHSPLKPYGCEECGKSYRLISLLNLHKKRHSGEARYRCEDCGKLFTTSGNLKRHQLVHSGEKPYQCDYCGRSFSDPTSKMRHLETHDTDKEHKCPHCDKKFNQVGNLKAHLKIHIADGPLKCRECGKQFTTSGNLKRHLRIHSGEKPYVCIHCQRQFADPGALQRHVRIHTGEKPCQCVMCGKAFTQASSLIAHVRQHTGEKPYVCERCGKRFVQSSQLANHIRHHDNIRPHKCSVCSKAFVNVGDLSKHIIIHTGEKPYLCDKCGRGFNRVDNLRSHVKTVHQGKAGIKILEPEEGSEVSVVTVDDMVTLATEALAATAVTQLTVVPVGAAVTADETEVLKAEISKAVKQVQEEDPNTHILYACDSCGDKFLDANSLAQHVRIHTAQALVMFQTDADFYQQYGPGGTWPAGQVLQAGELVFRPRDGAEGQPALAETSPTAPECPPPAE
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q13105 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S120 | Phosphorylation | Uniprot | |
| K135 | Ubiquitination | Uniprot | |
| S156 | Phosphorylation | Uniprot | |
| T157 | Phosphorylation | Uniprot | |
| S162 | Phosphorylation | Uniprot | |
| R169 | Methylation | Uniprot | |
| S175 | Phosphorylation | Uniprot | |
| S178 | Phosphorylation | Uniprot | |
| S271 | Phosphorylation | Uniprot | |
| T274 | Phosphorylation | Uniprot | |
| T291 | Phosphorylation | Uniprot | |
| Y292 | Phosphorylation | Uniprot | |
| T329 | Phosphorylation | Uniprot | |
| K332 | Ubiquitination | Uniprot | |
| K341 | Ubiquitination | Uniprot | |
| K350 | Ubiquitination | Uniprot | |
| T355 | Phosphorylation | Uniprot | |
| S357 | Phosphorylation | Uniprot | |
| K360 | Ubiquitination | Uniprot | |
| K406 | Ubiquitination | Uniprot | |
| S413 | Phosphorylation | Uniprot | |
| K433 | Acetylation | Uniprot | |
| K462 | Ubiquitination | Uniprot | |
| S497 | Phosphorylation | Uniprot | |
| T525 | Phosphorylation | Uniprot | |
| S570 | Phosphorylation | Uniprot | |
| T609 | Phosphorylation | Uniprot |
研究背景
Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49 isoform 3/ZNF509S1.
Undergoes 'Lys-48'-linked polyubiquitination at Lys-397 and Lys-481 and subsequent proteasomal degradation in a TRAF2-dependent manner.
Nucleus.
Expressed in germinal center B-cells.
Homooligomerizes (via the BTB/POZ domain), multimerization is required for DNA binding. Interacts (via the C-terminal zinc fingers) with GIF1; the interaction results in the recruitment of MYB to the CDKN1A/p21 and CDKN1B promoters and repression of transcription. Interacts with TRAF2, interfering with the binding of UBC13 to TRAF2, and inhibiting TRAF2 E3 ligase activity. Interacts with MYC (via the C-terminal helix-loop-helix motif); the interaction inhibits ZBTB17 transactivation and growth arrest activities and renders it insoluble in the nucleus. Also interacts with HCFC1, MAGEA4 and TMPRSS11A. Interacts with BCL6; the interaction inhibits ZBTB17 transactivation activity on target genes involved in cell cycle arrest. Interacts with ZBTB49 isoform 3/ZNF509S1; this interaction blocks ZBTB17-mediated repression of RB1.
Belongs to the krueppel C2H2-type zinc-finger protein family.
研究領域
· Cellular Processes > Cell growth and death > Cell cycle. (View pathway)
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Human Diseases > Cancers: Overview > Transcriptional misregulation in cancer.
· Human Diseases > Cancers: Specific types > Small cell lung cancer. (View pathway)
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