SFRS6 Antibody - #DF8824
| 製品: | SFRS6 Antibody |
| カタログ: | DF8824 |
| タンパク質の説明: | Rabbit polyclonal antibody to SFRS6 |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat |
| 予測: | Chicken |
| 分子量: | 40 kDa; 40kD(Calculated). |
| ユニプロット: | Q13247 |
| RRID: | AB_2842021 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF8824, RRID:AB_2842021.
折りたたみ／展開
arginine/serine-rich 6; B52; Epididymis secretory protein Li 91; fc17h09; HEL S 91; MGC128807; MGC5045; Pre mRNA splicing factor SRP55; Pre-mRNA-splicing factor SRP55; Serine/arginine-rich splicing factor 6; SFRS6; Splicing factor; Splicing factor arginine/serine rich 55 kDa; Splicing factor arginine/serine rich 6; SR splicing factor 6; SRP55; SRSF6; SRSF6_HUMAN; wu:faa54g02; wu:fc17h09; zgc:103497;
免疫原
- Q13247 SRSF6_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPRVYIGRLSYNVREKDIQRFFSGYGRLLEVDLKNGYGFVEFEDSRDADDAVYELNGKELCGERVIVEHARGPRRDRDGYSYGSRSGGGGYSSRRTSGRDKYGPPVRTEYRLIVENLSSRCSWQDLKDFMRQAGEVTYADAHKERTNEGVIEFRSYSDMKRALDKLDGTEINGRNIRLIEDKPRTSHRRSYSGSRSRSRSRRRSRSRSRRSSRSRSRSISKSRSRSRSRSKGRSRSRSKGRKSRSKSKSKPKSDRGSHSHSRSRSKDEYEKSRSRSRSRSPKENGKGDIKSKSRSRSQSRSNSPLPVPPSKARSVSPPPKRATSRSRSRSRSKSRSRSRSSSRD
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q13247 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S23 | Phosphorylation | Uniprot | |
| S45 | Phosphorylation | Uniprot | |
| Y53 | Phosphorylation | Uniprot | |
| K58 | Ubiquitination | Uniprot | |
| R71 | Methylation | Uniprot | |
| Y80 | Phosphorylation | Uniprot | |
| S81 | Phosphorylation | Uniprot | |
| Y82 | Phosphorylation | Uniprot | |
| S84 | Phosphorylation | Uniprot | |
| R85 | Methylation | Uniprot | |
| S86 | Phosphorylation | Uniprot | |
| Y91 | Phosphorylation | Uniprot | |
| S97 | Phosphorylation | Uniprot | |
| K101 | Acetylation | Uniprot | |
| K101 | Ubiquitination | Uniprot | |
| Y102 | Phosphorylation | Uniprot | |
| S118 | Phosphorylation | Uniprot | |
| S119 | Phosphorylation | Uniprot | |
| S122 | Phosphorylation | Uniprot | |
| K127 | Ubiquitination | Uniprot | |
| T137 | Phosphorylation | Uniprot | |
| Y138 | Phosphorylation | Uniprot | |
| K143 | Ubiquitination | Uniprot | |
| T146 | Phosphorylation | Uniprot | |
| S157 | Phosphorylation | Uniprot | |
| K165 | Acetylation | Uniprot | |
| K165 | Ubiquitination | Uniprot | |
| T169 | Phosphorylation | Uniprot | |
| K182 | Acetylation | Uniprot | |
| K182 | Ubiquitination | Uniprot | |
| S190 | Phosphorylation | Uniprot | |
| Y191 | Phosphorylation | Uniprot | |
| S192 | Phosphorylation | Uniprot | |
| S194 | Phosphorylation | Uniprot | |
| S196 | Phosphorylation | Uniprot | |
| S253 | Phosphorylation | Uniprot | |
| S257 | Phosphorylation | Uniprot | |
| S259 | Phosphorylation | Uniprot | |
| S261 | Phosphorylation | Uniprot | |
| S263 | Phosphorylation | Uniprot | |
| S265 | Phosphorylation | Uniprot | |
| Y269 | Phosphorylation | Uniprot | |
| S272 | Phosphorylation | Uniprot | |
| S274 | Phosphorylation | Uniprot | |
| K290 | Acetylation | Uniprot | |
| S291 | Phosphorylation | Uniprot | |
| S293 | Phosphorylation | Uniprot | |
| S295 | Phosphorylation | Uniprot | |
| S297 | Phosphorylation | Uniprot | |
| S299 | Phosphorylation | Uniprot | |
| S301 | Phosphorylation | Uniprot | |
| S303 | Phosphorylation | Uniprot | |
| S310 | Phosphorylation | Uniprot | |
| S314 | Phosphorylation | Uniprot | |
| S316 | Phosphorylation | Uniprot | |
| S326 | Phosphorylation | Uniprot |
研究背景
Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing.
Extensively phosphorylated on serine residues in the RS domain. Phosphorylated by DYRK1A, probably in the RS domain. Phosphorylation by DYRK1A modulates alternative splice site selection and inhibits the expression of MAPT/Tau exon 10.
Nucleus. Nucleus speckle.
Binds SREK1/SFRS12. Interacts with DYRK1A.
Belongs to the splicing factor SR family.
研究領域
· Genetic Information Processing > Transcription > Spliceosome.
· Human Diseases > Infectious diseases: Viral > Herpes simplex infection.
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