CBX8 Antibody - #DF8872
| 製品: | CBX8 Antibody |
| カタログ: | DF8872 |
| タンパク質の説明: | Rabbit polyclonal antibody to CBX8 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Sheep, Rabbit |
| 分子量: | 43 kDa; 43kD(Calculated). |
| ユニプロット: | Q9HC52 |
| RRID: | AB_2842068 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF8872, RRID:AB_2842068.
折りたたみ／展開
Cbx8; CBX8_HUMAN; Chromobox Homolog 8 (Drosophila Pc Class); Chromobox Homolog 8 (Pc Class Homolog, Drosophila); Chromobox Homolog 8; Chromobox protein homolog 8; hPc3; Pc Class 3 Homolog (Drosophila); Pc Class 3 Homolog; Pc3; Polycomb 3; Polycomb 3 homolog; RC1; Rectachrome 1;
免疫原
- Q9HC52 CBX8_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MELSAVGERVFAAEALLKRRIRKGRMEYLVKWKGWSQKYSTWEPEENILDARLLAAFEEREREMELYGPKKRGPKPKTFLLKAQAKAKAKTYEFRSDSARGIRIPYPGRSPQDLASTSRAREGLRNMGLSPPASSTSTSSTCRAEAPRDRDRDRDRDRERDRERERERERERERERERERGTSRVDDKPSSPGDSSKKRGPKPRKELPDPSQRPLGEPSAGLGEYLKGRKLDDTPSGAGKFPAGHSVIQLARRQDSDLVQCGVTSPSSAEATGKLAVDTFPARVIKHRAAFLEAKGQGALDPNGTRVRHGSGPPSSGGGLYRDMGAQGGRPSLIARIPVARILGDPEEESWSPSLTNLEKVVVTDVTSNFLTVTIKESNTDQGFFKEKR
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9HC52 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S4 | Phosphorylation | Uniprot | |
| Y28 | Phosphorylation | Uniprot | |
| K33 | Ubiquitination | Uniprot | |
| K70 | Ubiquitination | Uniprot | |
| S110 | Phosphorylation | Uniprot | |
| S130 | Phosphorylation | Uniprot | |
| S190 | Phosphorylation | Uniprot | |
| S191 | Phosphorylation | Uniprot | |
| K205 | Ubiquitination | Uniprot | |
| K227 | Ubiquitination | Uniprot | |
| T234 | Phosphorylation | Uniprot | |
| K240 | Acetylation | Uniprot | |
| S256 | Phosphorylation | Uniprot | |
| T264 | Phosphorylation | Uniprot | |
| S265 | Phosphorylation | Uniprot | |
| S268 | Phosphorylation | Uniprot | |
| K295 | Ubiquitination | Uniprot | |
| T305 | Phosphorylation | Uniprot | |
| S311 | Phosphorylation | Uniprot | |
| S315 | Phosphorylation | Uniprot | |
| Y321 | Phosphorylation | Uniprot | |
| S332 | Phosphorylation | Uniprot | |
| S352 | Phosphorylation | Uniprot | |
| S354 | Phosphorylation | Uniprot | |
| K386 | Ubiquitination | Uniprot |
研究背景
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
Nucleus.
Component of a PRC1-like complex. Interacts with RING1 RNF2, PCGF1, PCGF2, PCGF3, BMI1, PCGF5 AND PCGF6. Interacts with MLLT3 and histone H3. Interacts with PHC2 (By similarity).
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