ZHX2 Antibody - #DF8899
| 製品: | ZHX2 Antibody |
| カタログ: | DF8899 |
| タンパク質の説明: | Rabbit polyclonal antibody to ZHX2 |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 92 kDa; 92kD(Calculated). |
| ユニプロット: | Q9Y6X8 |
| RRID: | AB_2842095 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF8899, RRID:AB_2842095.
折りたたみ／展開
AFP regulator 1; AFR1; Alpha fetoprotein regulator 1; Alpha-fetoprotein regulator 1; KIAA0854; RAF; Regulator of AFP; Transcription factor ZHX2; ZHX2; ZHX2_HUMAN; Zinc finger and homeodomain protein 2; Zinc fingers and homeoboxes 2; Zinc fingers and homeoboxes protein 2;
免疫原
- Q9Y6X8 ZHX2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MASKRKSTTPCMVRTSQVVEQDVPEEVDRAKEKGIGTPQPDVAKDSWAAELENSSKENEVIEVKSMGESQSKKLQGGYECKYCPYSTQNLNEFTEHVDMQHPNVILNPLYVCAECNFTTKKYDSLSDHNSKFHPGEANFKLKLIKRNNQTVLEQSIETTNHVVSITTSGPGTGDSDSGISVSKTPIMKPGKPKADAKKVPKKPEEITPENHVEGTARLVTDTAEILSRLGGVELLQDTLGHVMPSVQLPPNINLVPKVPVPLNTTKYNSALDTNATMINSFNKFPYPTQAELSWLTAASKHPEEHIRIWFATQRLKHGISWSPEEVEEARKKMFNGTIQSVPPTITVLPAQLAPTKVTQPILQTALPCQILGQTSLVLTQVTSGSTTVSCSPITLAVAGVTNHGQKRPLVTPQAAPEPKRPHIAQVPEPPPKVANPPLTPASDRKKTKEQIAHLKASFLQSQFPDDAEVYRLIEVTGLARSEIKKWFSDHRYRCQRGIVHITSESLAKDQLAIAASRHGRTYHAYPDFAPQKFKEKTQGQVKILEDSFLKSSFPTQAELDRLRVETKLSRREIDSWFSERRKLRDSMEQAVLDSMGSGKKGQDVGAPNGALSRLDQLSGAQLTSSLPSPSPAIAKSQEQVHLLRSTFARTQWPTPQEYDQLAAKTGLVRTEIVRWFKENRCLLKTGTVKWMEQYQHQPMADDHGYDAVARKATKPMAESPKNGGDVVPQYYKDPKKLCEEDLEKLVTRVKVGSEPAKDCLPAKPSEATSDRSEGSSRDGQGSDENEESSVVDYVEVTVGEEDAISDRSDSWSQAAAEGVSELAESDSDCVPAEAGQA
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9Y6X8 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S7 | Phosphorylation | Uniprot | |
| T8 | Phosphorylation | Uniprot | |
| T9 | Phosphorylation | Uniprot | |
| T37 | Phosphorylation | Uniprot | |
| T207 | Phosphorylation | Uniprot | |
| T215 | Phosphorylation | Uniprot | |
| T220 | Phosphorylation | Uniprot | |
| T222 | Phosphorylation | Uniprot | |
| Y267 | Phosphorylation | Uniprot | |
| S269 | Phosphorylation | Uniprot | |
| T344 | Phosphorylation | Uniprot | |
| T355 | Phosphorylation | Uniprot | |
| T401 | Phosphorylation | Uniprot | |
| T411 | Phosphorylation | Uniprot | |
| T439 | Phosphorylation | Uniprot | |
| S442 | Phosphorylation | Uniprot | |
| K455 | Ubiquitination | Uniprot | |
| Y470 | Phosphorylation | Uniprot | |
| T566 | Phosphorylation | Uniprot | |
| S569 | Phosphorylation | Uniprot | |
| S586 | Phosphorylation | Uniprot | |
| S625 | Phosphorylation | Uniprot | |
| S628 | Phosphorylation | Uniprot | |
| T654 | Phosphorylation | Uniprot | |
| Y658 | Phosphorylation | Uniprot | |
| Y705 | Phosphorylation | Uniprot | |
| T713 | Phosphorylation | Uniprot | |
| S719 | Phosphorylation | Uniprot | |
| S769 | Phosphorylation | Uniprot | |
| S775 | Phosphorylation | Uniprot | |
| S776 | Phosphorylation | Uniprot |
研究背景
Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA. May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells (By similarity). In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex (By similarity).
Nucleus.
Note: Colocalizes with EFNB1 intracellular domain in the nucleus.
Ubiquitously expressed. Expressed in podocytes.
Homodimer (via homeobox domain). Heterodimer with ZHX1 (via homeobox domain 1). Heterodimer with ZHX3 (via homeobox domain 1). Heterodimerization with ZHX1 is not necessary for repressor activity. Interacts (via homeobox domain) with NFYA (via N-terminus). Interacts with EFNB1 intracellular domain peptide; the interaction enhances ZHX2 transcriptional repression activity (By similarity).
Belongs to the ZHX family.
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.