製品: CDK5RAP1 Antibody
カタログ: DF8915
タンパク質の説明: Rabbit polyclonal antibody to CDK5RAP1
アプリケーション: WB IHC IF/ICC
反応性: Human, Rat
予測: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
分子量: 67 kDa; 68kD(Calculated).
ユニプロット: Q96SZ6
RRID: AB_2842111

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 100ul $280 在庫あり
 200ul $350 在庫あり

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製品説明

ソース:
Rabbit
アプリケーション:
IF/ICC 1:100-1:500, IHC 1:50-1:200, WB 1:1000-3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Rat
予測:
Pig(100%), Zebrafish(88%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(88%), Xenopus(88%)
クローナリティ:
Polyclonal
特異性:
CDK5RAP1 Antibody detects endogenous levels of total CDK5RAP1.
RRID:
AB_2842111
引用形式: Affinity Biosciences Cat# DF8915, RRID:AB_2842111.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ/展開

2310066P17Rik; C20orf34; C42; CDK5 activator binding protein C42; CDK5 activator binding protein C42 like; CDK5 regulatory subunit associated protein 1; CDK5RAP1.3; CDK5RAP1.4; CGI 05; HSPC167; OTTMUSP00000016976; RP23-154J12.6; RP5-1187J4.1;

免疫原

免疫原:
Uniprot:
遺伝子(ID):
発現特異性:
Q96SZ6 CK5P1_HUMAN:

Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

タンパク質配列:
MHPLQCVLQVQRSLGWGPLASVSWLSLRMCRAHSSLSSTMCPSPERQEDGARKDFSSRLAAGPTFQHFLKSASAPQEKLSSEVEDPPPYLMMDELLGRQRKVYLETYGCQMNVNDTEIAWSILQKSGYLRTSNLQEADVILLVTCSIREKAEQTIWNRLHQLKALKTRRPRSRVPLRIGILGCMAERLKEEILNREKMVDILAGPDAYRDLPRLLAVAESGQQAANVLLSLDETYADVMPVQTSASATSAFVSIMRGCDNMCSYCIVPFTRGRERSRPIASILEEVKKLSEQVFLPPRPPKVLGLQGLKEVTLLGQNVNSFRDNSEVQFNSAVPTNLSRGFTTNYKTKQGGLRFAHLLDQVSRVDPEMRIRFTSPHPKDFPDEVLQLIHERDNICKQIHLPAQSGSSRVLEAMRRGYSREAYVELVHHIRESIPGVSLSSDFIAGFCGETEEDHVQTVSLLREVQYNMGFLFAYSMRQKTRAYHRLKDDVPEEVKLRRLEELITIFREEATKANQTSVGCTQLVLVEGLSKRSATDLCGRNDGNLKVIFPDAEMEDVNNPGLRVRAQPGDYVLVKITSASSQTLRGHVLCRTTLRDSSAYC

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Rabbit
100
Xenopus
88
Zebrafish
88
Chicken
88
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q96SZ6 基板として

Site PTM Type Enzyme
S37 Phosphorylation
K70 Ubiquitination
K78 Ubiquitination
K163 Ubiquitination
K189 Ubiquitination
K197 Ubiquitination
K287 Ubiquitination
R298 Methylation
K346 Ubiquitination
K378 Ubiquitination
K396 Ubiquitination
S406 Phosphorylation
Y422 Phosphorylation
Y483 Phosphorylation
K487 Ubiquitination
K495 Ubiquitination
K531 Ubiquitination
K546 Acetylation
K546 Ubiquitination
T583 Phosphorylation

研究背景

機能:

Specifically inhibits CDK5 activation by CDK5R1.

組織特異性:

Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

サブユニット構造:

Interacts with CDK5R1 (p35 form). CDK5RAP1, CDK5RAP2 and CDK5RAP3 show competitive binding to CDK5R1. Forms a complex with CDK5R1 and CDK5.

タンパク質ファミリー:

Belongs to the methylthiotransferase family. MiaB subfamily.

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