IL17F Antibody - #DF8981
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF8981, RRID:AB_2842177.
折りたたみ／展開
CANDF6; Cytokine ML 1; Cytokine ML-1; IL 17F; IL 24; IL-17F; Il17f; IL17F_HUMAN; Interleukin 17F; Interleukin 24; Interleukin-17F; ML 1; ML1; Mutant IL 17F; OTTHUMP00000016602;
免疫原
- Q96PD4 IL17F_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTVKTLHGPAMVKYLLLSILGLAFLSEAAARKIPKVGHTFFQKPESCPPVPGGSMKLDIGIINENQRVSMSRNIESRSTSPWNYTVTWDPNRYPSEVVQAQCRNLGCINAQGKEDISMNSVPIQQETLVVRRKHQGCSVSFQLEKVLVTVGCTCVTPVIHHVQ
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q96PD4 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| N83 | N-Glycosylation | Uniprot | |
| S117 | Phosphorylation | Uniprot |
研究背景
Ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in stimulating the production of other cytokines such as IL6, IL8 and CSF2, and in regulation of cartilage matrix turnover. Also involved in stimulating the proliferation of peripheral blood mononuclear cells and T-cells and in inhibition of angiogenesis. Plays a role in the induction of neutrophilia in the lungs and in the exacerbation of antigen-induced pulmonary allergic inflammation (By similarity).
Secreted.
Expressed in activated, but not resting, CD4+ T-cells and activated monocytes.
Homodimer; disulfide-linked. Heterodimer with IL17A.
Belongs to the IL-17 family.
研究領域
· Environmental Information Processing > Signaling molecules and interaction > Cytokine-cytokine receptor interaction. (View pathway)
· Human Diseases > Immune diseases > Inflammatory bowel disease (IBD).
· Organismal Systems > Immune system > IL-17 signaling pathway. (View pathway)
· Organismal Systems > Immune system > Th17 cell differentiation. (View pathway)
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