INGR2 Antibody - #DF8988
| 製品: | INGR2 Antibody |
| カタログ: | DF8988 |
| タンパク質の説明: | Rabbit polyclonal antibody to INGR2 |
| アプリケーション: | WB |
| 反応性: | Human |
| 予測: | Bovine, Sheep, Rabbit, Dog |
| 分子量: | 38 kDa; 38kD(Calculated). |
| ユニプロット: | P38484 |
| RRID: | AB_2842184 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF8988, RRID:AB_2842184.
折りたたみ／展開
AF 1; AF-1; AF1; IFGR 2; IFGR2; IFN-gamma receptor 2; IFN-gamma-R2; IFNGR 2; IFNGR2; IFNGT 1; IFNGT1; IMD28; INGR2_HUMAN; Interferon gamma receptor 2 (interferon gamma transducer 1); Interferon gamma receptor 2; Interferon gamma receptor accessory factor 1; Interferon gamma receptor beta chain; Interferon gamma receptor chain 2; Interferon gamma transducer 1;
免疫原
- P38484 INGR2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MRPTLLWSLLLLLGVFAAAAAAPPDPLSQLPAPQHPKIRLYNAEQVLSWEPVALSNSTRPVVYQVQFKYTDSKWFTADIMSIGVNCTQITATECDFTAASPSAGFPMDFNVTLRLRAELGALHSAWVTMPWFQHYRNVTVGPPENIEVTPGEGSLIIRFSSPFDIADTSTAFFCYYVHYWEKGGIQQVKGPFRSNSISLDNLKPSRVYCLQVQAQLLWNKSNIFRVGHLSNISCYETMADASTELQQVILISVGTFSLLSVLAGACFFLVLKYRGLIKYWFHTPPSIPLQIEEYLKDPTQPILEALDKDSSPKDDVWDSVSIISFPEKEQEDVLQTL
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P38484 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| N56 | N-Glycosylation | Uniprot | |
| N85 | N-Glycosylation | Uniprot | |
| N110 | N-Glycosylation | Uniprot | |
| N137 | N-Glycosylation | Uniprot | |
| S198 | Phosphorylation | Uniprot | |
| N219 | N-Glycosylation | Uniprot | |
| N231 | N-Glycosylation | Uniprot | |
| K308 | Ubiquitination | Uniprot | |
| S324 | Phosphorylation | Uniprot | |
| T336 | Phosphorylation | Uniprot |
研究背景
Associates with IFNGR1 to form a receptor for the cytokine interferon gamma (IFNG). Ligand binding stimulates activation of the JAK/STAT signaling pathway. Required for signal transduction in contrast to other receptor subunit responsible for ligand binding.
Cell membrane>Single-pass type I membrane protein. Cytoplasmic vesicle membrane>Single-pass type I membrane protein. Golgi apparatus membrane>Single-pass type I membrane protein. Endoplasmic reticulum membrane>Single-pass type I membrane protein. Cytoplasm.
Note: Has low cell surface expression and high cytoplasmic expression in T cells. The bias towards cytoplasmic expression may be due to ligand-independent receptor internalization and recycling.
Expressed in T-cells (at protein level).
Heterodimer with IFNGR1, to form the IFNG receptor complex. Interacts (via intracellular domain) with JAK2.
Belongs to the type II cytokine receptor family.
研究領域
· Cellular Processes > Cell growth and death > Necroptosis. (View pathway)
· Environmental Information Processing > Signaling molecules and interaction > Cytokine-cytokine receptor interaction. (View pathway)
· Environmental Information Processing > Signal transduction > HIF-1 signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Jak-STAT signaling pathway. (View pathway)
· Human Diseases > Infectious diseases: Bacterial > Salmonella infection.
· Human Diseases > Infectious diseases: Parasitic > Leishmaniasis.
· Human Diseases > Infectious diseases: Parasitic > Chagas disease (American trypanosomiasis).
· Human Diseases > Infectious diseases: Parasitic > Toxoplasmosis.
· Human Diseases > Infectious diseases: Bacterial > Tuberculosis.
· Human Diseases > Infectious diseases: Viral > Measles.
· Human Diseases > Infectious diseases: Viral > Influenza A.
· Human Diseases > Infectious diseases: Viral > Herpes simplex infection.
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Human Diseases > Immune diseases > Inflammatory bowel disease (IBD).
· Organismal Systems > Development > Osteoclast differentiation. (View pathway)
· Organismal Systems > Immune system > Natural killer cell mediated cytotoxicity. (View pathway)
· Organismal Systems > Immune system > Th1 and Th2 cell differentiation. (View pathway)
· Organismal Systems > Immune system > Th17 cell differentiation. (View pathway)
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