MYST3 Antibody - #DF9024
(2)
(4)
| 製品: | MYST3 Antibody |
| カタログ: | DF9024 |
| タンパク質の説明: | Rabbit polyclonal antibody to MYST3 |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| 分子量: | 225 kDa; 225kD(Calculated). |
| ユニプロット: | Q92794 |
| RRID: | AB_2842220 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF9024, RRID:AB_2842220.
折りたたみ／展開
HAT 3; Histone acetyltransferase MYST3; Monocytic leukemia zinc finger protein; MOZ; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3; MYST histone acetyltransferase (monocytic leukemia) 3; MYST protein 3; MYST-3; MYST3; MYST3_HUMAN; OTTHUMP00000197392; OTTHUMP00000197394; OTTHUMP00000225722; Runt related transcription factor binding protein 2; Runt-related transcription factor-binding protein 2; RUNXBP2; SAS2; SAS2 and TIP60 protein 3; TIP60 protein 3; YBF2/SAS3; ZC2HC6A; Zinc finger protein 220; ZNF220;
免疫原
- Q92794 KAT6A_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTILKVSNKGLNSYKDPDNPGRIALPKPRNHGKLDNKQNVDWNKLIKRAVEGLAESGGSTLKSIERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTKATNVDGKESCESLSCLPPVSLLPHEKDKPVAEPIPICSFCLGTKEQNREKKPEELISCADCGNSGHPSCLKFSPELTVRVKALRWQCIECKTCSSCRDQGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICRPRKKGRKLLQKKAAQIKRRYTNPIGRPKNRLKKQNTVSKGPFSKVRTGPGRGRKRKITLSSQSASSSSEEGYLERIDGLDFCRDSNVSLKFNKKTKGLIDGLTKFFTPSPDGRKARGEVVDYSEQYRIRKRGNRKSSTSDWPTDNQDGWDGKQENEERLFGSQEIMTEKDMELFRDIQEQALQKVGVTGPPDPQVRCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLCEFCLKYMKSRTILQQHMKKCGWFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTQNDVKGCHLVGYFSKEKHCQQKYNVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQAGSPEKPLSDLGRLSYMAYWKSVILECLYHQNDKQISIKKLSKLTGICPQDITSTLHHLRMLDFRSDQFVIIRREKLIQDHMAKLQLNLRPVDVDPECLRWTPVIVSNSVVSEEEEEEAEEGENEEPQCQERELEISVGKSVSHENKEQDSYSVESEKKPEVMAPVSSTRLSKQVLPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLLEETSSAPQEQYGECGEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRGQLKKSPEALKCRLTEGSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILTKPTLKRKKPFLHRRRRVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEEEDENELFPREYFRRLSSQDVLRCQSSSKRKSKDEEEDEESDDADDTPILKPVSLLRKRDVKNSPLEPDTSTPLKKKKGWPKGKSRKPIHWKKRPGRKPGFKLSREIMPVSTQACVIEPIVSIPKAGRKPKIQESEETVEPKEDMPLPEERKEEEEMQAEAEEAEEGEEEDAASSEVPAASPADSSNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAETAQNDDHDADDEDDGHLESTKKKELEEQPTREDVKEEPGVQESFLDANMQKSREKIKDKEETELDSEEEQPSHDTSVVSEQMAGSEDDHEEDSHTKEELIELKEEEEIPHSELDLETVQAVQSLTQEESSEHEGAYQDCEETLAACQTLQSYTQADEDPQMSMVEDCHASEHNSPISSVQSHPSQSVRSVSSPNVPALESGYTQISPEQGSLSAPSMQNMETSPMMDVPSVSDHSQQVVDSGFSDLGSIESTTENYENPSSYDSTMGGSICGNSSSQSSCSYGGLSSSSSLTQSSCVVTQQMASMGSSCSMMQQSSVQPAANCSIKSPQSCVVERPPSNQQQQPPPPPPQQPQPPPPQPQPAPQPPPPQQQPQQQPQPQPQQPPPPPPPQQQPPLSQCSMNNSFTPAPMIMEIPESGSTGNISIYERIPGDFGAGSYSQPSATFSLAKLQQLTNTIMDPHAMPYSHSPAVTSYATSVSLSNTGLAQLAPSHPLAGTPQAQATMTPPPNLASTTMNLTSPLLQCNMSATNIGIPHTQRLQGQMPVKGHISIRSKSAPLPSAAAHQQQLYGRSPSAVAMQAGPRALAVQRGMNMGVNLMPTPAYNVNSMNMNTLNAMNSYRMTQPMMNSSYHSNPAYMNQTAQYPMQMQMGMMGSQAYTQQPMQPNPHGNMMYTGPSHHSYMNAAGVPKQSLNGPYMRR
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q92794 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S28 | Phosphorylation | Uniprot | |
| S116 | Phosphorylation | Uniprot | |
| T117 | Phosphorylation | Uniprot | |
| S132 | Phosphorylation | Uniprot | |
| S138 | Phosphorylation | Uniprot | |
| S141 | Phosphorylation | Uniprot | |
| S245 | Phosphorylation | Uniprot | |
| T332 | Phosphorylation | Uniprot | |
| T347 | Phosphorylation | Uniprot | |
| K350 | Acetylation | Uniprot | |
| K355 | Acetylation | Uniprot | |
| T369 | Phosphorylation | P31749 (AKT1) | Uniprot |
| S379 | Phosphorylation | Uniprot | |
| Y383 | Phosphorylation | Uniprot | |
| K415 | Acetylation | Uniprot | |
| K415 | Ubiquitination | Uniprot | |
| T418 | Phosphorylation | Uniprot | |
| S420 | Phosphorylation | Uniprot | |
| Y433 | Phosphorylation | Uniprot | |
| Y437 | Phosphorylation | Uniprot | |
| S447 | Phosphorylation | Uniprot | |
| S448 | Phosphorylation | Uniprot | |
| T449 | Phosphorylation | Uniprot | |
| S450 | Phosphorylation | Uniprot | |
| K463 | Ubiquitination | Uniprot | |
| S473 | Phosphorylation | Uniprot | |
| K480 | Ubiquitination | Uniprot | |
| K495 | Ubiquitination | Uniprot | |
| K604 | Acetylation | Uniprot | |
| S678 | Phosphorylation | Uniprot | |
| S787 | Phosphorylation | Uniprot | |
| S812 | Phosphorylation | Uniprot | |
| K815 | Acetylation | Uniprot | |
| S826 | Phosphorylation | Uniprot | |
| S828 | Phosphorylation | Uniprot | |
| S842 | Phosphorylation | Uniprot | |
| C902 | S-Nitrosylation | Uniprot | |
| T909 | Phosphorylation | Uniprot | |
| S941 | Phosphorylation | Uniprot | |
| S954 | Phosphorylation | Uniprot | |
| S974 | Phosphorylation | Uniprot | |
| S996 | Phosphorylation | Uniprot | |
| S999 | Phosphorylation | Uniprot | |
| S1001 | Phosphorylation | Uniprot | |
| K1007 | Acetylation | Uniprot | |
| K1014 | Acetylation | Uniprot | |
| T1042 | Phosphorylation | Uniprot | |
| S1052 | Phosphorylation | Uniprot | |
| S1054 | Phosphorylation | Uniprot | |
| S1089 | Phosphorylation | Uniprot | |
| S1090 | Phosphorylation | Uniprot | |
| S1104 | Phosphorylation | Uniprot | |
| S1113 | Phosphorylation | Uniprot | |
| T1119 | Phosphorylation | Uniprot | |
| S1126 | Phosphorylation | Uniprot | |
| S1136 | Phosphorylation | Uniprot | |
| T1142 | Phosphorylation | Uniprot | |
| S1143 | Phosphorylation | Uniprot | |
| T1144 | Phosphorylation | Uniprot | |
| K1147 | Methylation | Uniprot | |
| K1148 | Methylation | Uniprot | |
| K1174 | Methylation | Uniprot | |
| K1330 | Methylation | Uniprot | |
| Y1732 | Phosphorylation | Uniprot | |
| S1861 | Phosphorylation | Uniprot | |
| R1877 | Methylation | Uniprot | |
| R1889 | Methylation | Uniprot | |
| R2003 | Methylation | Uniprot | |
| R2004 | Methylation | Uniprot |
研究背景
Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML.
Autoacetylation at Lys-604 is required for proper function (By similarity). Autoacetylated.
Phosphorylation at Thr-369 by PKB/AKT1 inhibits its interaction with PML and negatively regulates its acetylation activity towards p53/TP53.
Nucleus. Nucleus>Nucleolus. Nucleus>Nucleoplasm. Nucleus>PML body.
Note: Recruited into PML body after DNA damage.
Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3. Interacts with RUNX1; phosphorylation of RUNX1 enhances the interaction. Interacts with RUNX2. Interacts with p53/TP53. Interacts with PML (isoform PML-4) and this interaction positively regulates its acetylation activity towards p53/TP53.
The N-terminus is involved in transcriptional activation while the C-terminus is involved in transcriptional repression.
Belongs to the MYST (SAS/MOZ) family.
研究領域
· Cellular Processes > Cellular community - eukaryotes > Signaling pathways regulating pluripotency of stem cells. (View pathway)
参考文献
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