ACAA2 Antibody - #DF9062
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF9062, RRID:AB_2842258.
折りたたみ／展開
3 ketoacyl CoA thiolase; 3 ketoacyl CoA thiolase mitochondrial; 3-ketoacyl-CoA thiolase, mitochondrial; 3-oxoacyl-CoA thiolase, mitochondrial; ACAA 2; Acaa2; Acetyl CoA acyltransferase 2; Acetyl CoA acyltransferase; Acetyl Coenzyme A acyltransferase 2; Acetyl-CoA acyltransferase; Beta ketothiolase; Beta-ketothiolase; DSAEC; Mitochondrial 3 oxoacyl CoA thiolase; Mitochondrial 3 oxoacyl Coenzyme A thiolase; Mitochondrial 3-oxoacyl-CoA thiolase; T1; THIM_HUMAN;
免疫原
- P42765 THIM_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MALLRGVFVVAAKRTPFGAYGGLLKDFTATDLSEFAAKAALSAGKVSPETVDSVIMGNVLQSSSDAIYLARHVGLRVGIPKETPALTINRLCGSGFQSIVNGCQEICVKEAEVVLCGGTESMSQAPYCVRNVRFGTKLGSDIKLEDSLWVSLTDQHVQLPMAMTAENLAVKHKISREECDKYALQSQQRWKAANDAGYFNDEMAPIEVKTKKGKQTMQVDEHARPQTTLEQLQKLPPVFKKDGTVTAGNASGVADGAGAVIIASEDAVKKHNFTPLARIVGYFVSGCDPSIMGIGPVPAISGALKKAGLSLKDMDLVEVNEAFAPQYLAVERSLDLDISKTNVNGGAIALGHPLGGSGSRITAHLVHELRRRGGKYAVGSACIGGGQGIAVIIQSTA
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P42765 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K13 | Acetylation | Uniprot | |
| Y20 | Phosphorylation | Uniprot | |
| K25 | Acetylation | Uniprot | |
| K38 | Acetylation | Uniprot | |
| K38 | Ubiquitination | Uniprot | |
| Y68 | Phosphorylation | Uniprot | |
| K81 | Acetylation | Uniprot | |
| K81 | Ubiquitination | Uniprot | |
| T87 | Phosphorylation | Uniprot | |
| T119 | Phosphorylation | Uniprot | |
| S121 | Phosphorylation | Uniprot | |
| Y127 | Phosphorylation | Uniprot | |
| K137 | Acetylation | Uniprot | |
| K137 | Ubiquitination | Uniprot | |
| S140 | Phosphorylation | Uniprot | |
| K181 | Acetylation | Uniprot | |
| K181 | Ubiquitination | Uniprot | |
| Y182 | Phosphorylation | Uniprot | |
| K191 | Ubiquitination | Uniprot | |
| Y198 | Phosphorylation | Uniprot | |
| K234 | Acetylation | Uniprot | |
| K234 | Ubiquitination | Uniprot | |
| K240 | Acetylation | Uniprot | |
| K241 | Acetylation | Uniprot | |
| K241 | Ubiquitination | Uniprot | |
| K269 | Acetylation | Uniprot | |
| K269 | Ubiquitination | Uniprot | |
| K270 | Acetylation | Uniprot | |
| T274 | Phosphorylation | Uniprot | |
| K305 | Acetylation | Uniprot | |
| K306 | Acetylation | Uniprot | |
| S310 | Phosphorylation | Uniprot | |
| S333 | Phosphorylation | Uniprot | |
| S339 | Phosphorylation | Uniprot | |
| R370 | Methylation | Uniprot |
研究背景
In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (Probable). Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain unbranched 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (Probable). Also catalyzes the condensation of two acetyl-CoA molecules into acetoacetyl-CoA and could be involved in the production of ketone bodies (Probable). Also displays hydrolase activity on various fatty acyl-CoAs. Thereby, could be responsible for the production of acetate in a side reaction to beta-oxidation (Probable). Abolishes BNIP3-mediated apoptosis and mitochondrial damage.
Mitochondrion.
Homotetramer. Interacts with BNIP3.
Belongs to the thiolase-like superfamily. Thiolase family.
研究領域
· Metabolism > Lipid metabolism > Fatty acid elongation.
· Metabolism > Lipid metabolism > Fatty acid degradation.
· Metabolism > Amino acid metabolism > Valine, leucine and isoleucine degradation.
· Metabolism > Global and overview maps > Metabolic pathways.
· Metabolism > Global and overview maps > Fatty acid metabolism.
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