ADAM28 Antibody - #DF9163
(2)
(2)
| 製品: | ADAM28 Antibody |
| カタログ: | DF9163 |
| タンパク質の説明: | Rabbit polyclonal antibody to ADAM28 |
| アプリケーション: | WB |
| 反応性: | Human, Rat, Monkey |
| 予測: | Pig, Rabbit, Dog |
| 分子量: | 87kDa; 87kD(Calculated). |
| ユニプロット: | Q9UKQ2 |
| RRID: | AB_2842359 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF9163, RRID:AB_2842359.
折りたたみ／展開
A disintegrin and metalloproteinase domain 28; ADAM 28; ADAM metallopeptidase domain 28; ADAM23; Disintegrin and metalloproteinase domain containing protein 28; eMDC II; eMDCII; epididymal Metalloproteinase like disintegrin like and cysteine rich protein II; MDC L; MDCL; Metalloproteinase like disintegrin like and cysteine rich protein L;
免疫原
Expressed predominantly in secondary lymphoid tissues, such as lymph node, spleen, small intestine, stomach, colon, appendix and trachea. The lymphocyte population is responsible for expression of this protein in these tissues. Isoform 2 is expressed preferentially in spleen.
- Q9UKQ2 ADA28_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLQGLLPVSLLLSVAVSAIKELPGVKKYEVVYPIRLHPLHKREAKEPEQQEQFETELKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVSDASISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTCGMDGVLWAHDLQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDIAQLITATELAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDDYSCKCPSTICVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQFKKAGMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGPGTEVADKSCYNRNEGGSKYGYCRRVDDTLIPCKANDTMCGKLFCQGGSDNLPWKGRIVTFLTCKTFDPEDTSQEIGMVANGTKCGDNKVCINAECVDIEKAYKSTNCSSKCKGHAVCDHELQCQCEEGWIPPDCDDSSVVFHFSIVVGVLFPMAVIFVVVAMVIRHQSSREKQKKDQRPLSTTGTRPHKQKRKPQMVKAVQPQEMSQMKPHVYDLPVEGNEPPASFHKDTNALPPTVFKDNPVSTPKDSNPKA
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9UKQ2 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y28 | Phosphorylation | Uniprot | |
| Y237 | Phosphorylation | Uniprot | |
| S282 | Phosphorylation | Uniprot |
研究背景
May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. May be involved in sperm maturation.
Pro-domain removal and maturation may be, at least in part, autocatalytic.
Cell membrane>Single-pass type I membrane protein.
Secreted.
Expressed predominantly in secondary lymphoid tissues, such as lymph node, spleen, small intestine, stomach, colon, appendix and trachea. The lymphocyte population is responsible for expression of this protein in these tissues. Isoform 2 is expressed preferentially in spleen.
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
参考文献
Application: WB Species: Human Sample: gastric epithelial cells and gastric cancer cell
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