ALDH1A3 Antibody - #DF9187
| 製品: | ALDH1A3 Antibody |
| カタログ: | DF9187 |
| タンパク質の説明: | Rabbit polyclonal antibody to ALDH1A3 |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit |
| 分子量: | 56 kDa; 56kD(Calculated). |
| ユニプロット: | P47895 |
| RRID: | AB_2842383 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF9187, RRID:AB_2842383.
折りたたみ／展開
Acetaldehyde dehydrogenase 6; AL1A3_HUMAN; Aldehyde dehydrogenase 1A3; Aldehyde dehydrogenase 6; Aldehyde dehydrogenase family 1 member A3; Aldh1a3; ALDH1A6; ALDH6; RALDH 3; Retinaldehyde dehydrogenase 3; V1;
免疫原
Expressed at low levels in many tissues and at higher levels in salivary gland, stomach, and kidney.
- P47895 AL1A3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MATANGAVENGQPDRKPPALPRPIRNLEVKFTKIFINNEWHESKSGKKFATCNPSTREQICEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETMDTGKPFLHAFFIDLEGCIRTLRYFAGWADKIQGKTIPTDDNVVCFTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPILKFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWINCYNALYAQAPFGGFKMSGNGRELGEYALAEYTEVKTVTIKLGDKNP
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P47895 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| K30 | Ubiquitination | Uniprot | |
| K33 | Ubiquitination | Uniprot | |
| K44 | Ubiquitination | Uniprot | |
| T56 | Phosphorylation | Uniprot | |
| K150 | Ubiquitination | Uniprot | |
| K154 | Ubiquitination | Uniprot | |
| K252 | Ubiquitination | Uniprot | |
| K263 | Ubiquitination | Uniprot | |
| K266 | Ubiquitination | Uniprot | |
| T278 | Phosphorylation | Uniprot | |
| Y327 | Phosphorylation | Uniprot | |
| S328 | Phosphorylation | Uniprot | |
| K340 | Ubiquitination | Uniprot | |
| K350 | Ubiquitination | Uniprot | |
| K360 | Ubiquitination | Uniprot | |
| K364 | Ubiquitination | Uniprot | |
| K373 | Ubiquitination | Uniprot | |
| K394 | Ubiquitination | Uniprot | |
| K409 | Ubiquitination | Uniprot | |
| K421 | Ubiquitination | Uniprot | |
| K423 | Ubiquitination | Uniprot | |
| S424 | Phosphorylation | Uniprot | |
| K430 | Ubiquitination | Uniprot | |
| Y437 | Phosphorylation | Uniprot | |
| T440 | Phosphorylation | Uniprot | |
| K446 | Ubiquitination | Uniprot | |
| Y492 | Phosphorylation | Uniprot | |
| Y497 | Phosphorylation | Uniprot | |
| T498 | Phosphorylation | Uniprot |
研究背景
NAD-dependent aldehyde dehydrogenase that catalyzes the formation of retinoic acid. Has high activity with all-trans retinal, and has much lower in vitro activity with acetaldehyde. Required for the biosynthesis of normal levels of retinoic acid in the embryonic ocular and nasal regions; retinoic acid is required for normal embryonic development of the eye and the nasal region (By similarity).
Cytoplasm.
Expressed at low levels in many tissues and at higher levels in salivary gland, stomach, and kidney.
Homotetramer.
Belongs to the aldehyde dehydrogenase family.
研究領域
· Human Diseases > Cancers: Overview > Chemical carcinogenesis.
· Metabolism > Carbohydrate metabolism > Glycolysis / Gluconeogenesis.
· Metabolism > Amino acid metabolism > Histidine metabolism.
· Metabolism > Amino acid metabolism > Tyrosine metabolism.
· Metabolism > Amino acid metabolism > Phenylalanine metabolism.
· Metabolism > Metabolism of other amino acids > beta-Alanine metabolism.
· Metabolism > Xenobiotics biodegradation and metabolism > Metabolism of xenobiotics by cytochrome P450.
· Metabolism > Xenobiotics biodegradation and metabolism > Drug metabolism - cytochrome P450.
· Metabolism > Global and overview maps > Metabolic pathways.
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