AKR1C1 Antibody - #DF9189
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF9189, RRID:AB_2842385.
折りたたみ／展開
2-dihydrobenzene-1; 2-diol dehydrogenase; 20 alpha (3 alpha) hydroxysteroid dehydrogenase; 20 ALPHA HSD; 20 alpha hydroxysteroid dehydrogenase; 20-alpha-HSD; 20-alpha-hydroxysteroid dehydrogenase; 20ALPHAHSD; 2ALPHAHSD; AK1C1; AK1C1_HUMAN; AKR1C1; Aldo keto reductase family 1 member C1; aldo-keto reductase C; Aldo-keto reductase family 1 member C1; Aldo-keto reductase family, 1 member 1; C9; Chlordecone reductase homolog; Chlordecone reductase homolog HAKRC; DD1; DD1/DD2; DDH; DDH1; Dihydrodiol dehydrogenase 1; Dihydrodiol dehydrogenase 1/2; dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase; dihydrodiol dehydrogenase isoform DD1; Dihydrodiol dehydrogenase, type 1; H37; HAKRC; HBAB; Hepatic dihydrodiol dehydrogenase; High affinity hepatic bile acid-binding protein; High-affinity hepatic bile acid-binding protein; Indanol dehydrogenase; MBAB; MGC8954; Trans-1; Trans-1,2 dihydrobenzene 1,2 diol dehydrogenase; Type II 3 alpha hydroxysteroid dehydrogenase;
免疫原
Expressed in all tissues tested including liver, prostate, testis, adrenal gland, brain, uterus, mammary gland and keratinocytes. Highest levels found in liver, mammary gland and brain.
- Q04828 AK1C1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEATKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLTLDIFAGPPNYPFSDEY
PTMs - Q04828 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K4 | Acetylation | Uniprot | |
| K4 | Sumoylation | Uniprot | |
| K4 | Ubiquitination | Uniprot | |
| Y5 | Phosphorylation | Uniprot | |
| K9 | Sumoylation | Uniprot | |
| K9 | Ubiquitination | Uniprot | |
| T23 | Phosphorylation | Uniprot | |
| Y24 | Phosphorylation | Uniprot | |
| K31 | Ubiquitination | Uniprot | |
| S32 | Phosphorylation | Uniprot | |
| K33 | Ubiquitination | Uniprot | |
| T38 | Phosphorylation | Uniprot | |
| K39 | Ubiquitination | Uniprot | |
| S51 | Phosphorylation | Uniprot | |
| Y55 | Phosphorylation | Uniprot | |
| S67 | Phosphorylation | Uniprot | |
| K68 | Ubiquitination | Uniprot | |
| S73 | Phosphorylation | Uniprot | |
| K75 | Acetylation | Uniprot | |
| K75 | Sumoylation | Uniprot | |
| K75 | Ubiquitination | Uniprot | |
| Y81 | Phosphorylation | Uniprot | |
| T82 | Phosphorylation | Uniprot | |
| S83 | Phosphorylation | Uniprot | |
| K84 | Ubiquitination | Uniprot | |
| K104 | Sumoylation | Uniprot | |
| K104 | Ubiquitination | Uniprot | |
| Y110 | Phosphorylation | Uniprot | |
| K123 | Ubiquitination | Uniprot | |
| K131 | Sumoylation | Uniprot | |
| T141 | Phosphorylation | Uniprot | |
| K161 | Ubiquitination | Uniprot | |
| S162 | Phosphorylation | Uniprot | |
| S166 | Phosphorylation | Uniprot | |
| K179 | Ubiquitination | Uniprot | |
| K183 | Ubiquitination | Uniprot | |
| Y184 | Phosphorylation | Uniprot | |
| K185 | Ubiquitination | Uniprot | |
| Y196 | Phosphorylation | Uniprot | |
| K201 | Ubiquitination | Uniprot | |
| K207 | Ubiquitination | Uniprot | |
| S208 | Phosphorylation | Uniprot | |
| K209 | Ubiquitination | Uniprot | |
| S232 | Phosphorylation | Uniprot | |
| K246 | Acetylation | Uniprot | |
| K246 | Ubiquitination | Uniprot | |
| K247 | Acetylation | Uniprot | |
| K247 | Ubiquitination | Uniprot | |
| K270 | Acetylation | Uniprot | |
| K270 | Ubiquitination | Uniprot | |
| Y272 | Phosphorylation | Uniprot | |
| K294 | Ubiquitination | Uniprot | |
| Y305 | Phosphorylation | Uniprot | |
| Y317 | Phosphorylation | Uniprot |
研究背景
Converts progesterone to its inactive form, 20-alpha-dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. Has a low bile-binding ability. May play a role in myelin formation.
Cytoplasm.
Expressed in all tissues tested including liver, prostate, testis, adrenal gland, brain, uterus, mammary gland and keratinocytes. Highest levels found in liver, mammary gland and brain.
Monomer.
Belongs to the aldo/keto reductase family.
研究領域
· Metabolism > Lipid metabolism > Steroid hormone biosynthesis.
· Metabolism > Xenobiotics biodegradation and metabolism > Metabolism of xenobiotics by cytochrome P450.
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