AAT1 Antibody - #DF9201
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF9201, RRID:AB_2842397.
折りたたみ／展開
AAT 1; AAT-1; AAT1 alpha; AAT1; AAT1_HUMAN; AAT1alpha; AMY 1 associating protein expressed in testis 1; AMY-1-associating protein expressed in testis 1; Chromosome 3 open reading frame 15; MYCBP binding protein;
免疫原
Isoform 1 is strongly expressed in the liver. Isoform 7 is widely expressed, but strongly expressed in all spermatogenesis-related tissues, including the testis, the epithelium of cauda and the corpus epididymis, as well as the spermatid and mature sperm. Isoform 7 is also expressed in Leydig cells. Isoform 3 is expressed in the testis.
- Q7Z4T9 CFA91_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSHAVTIEEPQAQPQVSQTRYRERSRAGSHISSNRAYDFLYDPLFIVSSEKDHTQANIQATLIRSRLRKVPRFKTMFSNLIHYPRYSLYWSKSDPVPPFISREWKGHKEKHREALRQLTTTDASFQMPKEVYEDPEVTGKNRYKYFERPFLPFFQQMPFNVVYAVSKAEPYTFPPTSTKHLSIPSKSTVGTQTDYRDADVQTDPYSAEYVVCQDSIPELLTLATLTWGRGLPAGQAEVEMIERAREKRAWEASLPALSDTSQFEKRRKMMNEMERKEWAFREQEIEKLQEIRLEVLKELLRKREENQNEVNMKHLNARWSKLQEGKEAKMAKIQRTHVSTIRKLVGKRKNIEGKLERRNIIKDYSDYASQVYGPLSRLGCFPDNNSEDFVVKNYYLNTYEGLVELESCLPDFVTQPQIRAPKPKVITTKAGFLKRAARLDYELAEVHKALLDKKNKVLEVKKPPRFLQRNPIPQPRLPTPTLEMTSNEEEEMEMAVIYLQKLLRGRVVQNMMFEGKEKRLELIQELRTCHALQEDEKLVKKAEKQVTLALQRQRNLHEHKVSLVENHLAGLEGRALADMFDFLSKELVRLQEERRIHAFVMLAERQRRVREAEESGRRQVEKQRLREEDEIFKEVVKVHHSTISSYLEDIILNTEANTAEEQARAEIEKMAEKINDIAYEMESRRTYLQSEEIVAELVYSFLIPEVQKYFVKEKVRNAQRKHILAAHQIIHSYTESMVQKKLTEGEQDEASNAAMLLEKETQNENNS
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q7Z4T9 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y86 | Phosphorylation | Uniprot | |
| S87 | Phosphorylation | Uniprot | |
| Y89 | Phosphorylation | Uniprot | |
| S91 | Phosphorylation | Uniprot | |
| Y132 | Phosphorylation | Uniprot | |
| T193 | Phosphorylation | Uniprot | |
| K297 | Ubiquitination | Uniprot | |
| K302 | Ubiquitination | Uniprot |
研究背景
May play a role in spermatogenesis. May regulate cilium motility through its role in the assembly of the axonemal radial spokes (By similarity).
Phosphorylated by PKA.
Mitochondrion. Cytoplasm. Cytoplasm>Cytoskeleton>Cilium axoneme.
Note: Localized in the neck of the sperm.
Isoform 1 is strongly expressed in the liver. Isoform 7 is widely expressed, but strongly expressed in all spermatogenesis-related tissues, including the testis, the epithelium of cauda and the corpus epididymis, as well as the spermatid and mature sperm. Isoform 7 is also expressed in Leydig cells. Isoform 3 is expressed in the testis.
Interacts with MYCBP and AKAP1. Part of a complex containing MYCBP, AKAP1 and PRKAR2B. Isoform 3 does not interact with MYCBP.
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