MT-ATP8 Antibody - #DF9240
| 製品: | MT-ATP8 Antibody |
| カタログ: | DF9240 |
| タンパク質の説明: | Rabbit polyclonal antibody to MT-ATP8 |
| アプリケーション: | WB |
| 反応性: | Human |
| 分子量: | 8 kDa; 8kD(Calculated). |
| ユニプロット: | P03928 |
| RRID: | AB_2842436 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF9240, RRID:AB_2842436.
免疫原
- P03928 ATP8_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPQLNTTVWPTMITPMLLTLFLITQLKMLNTNYHLPPSPKPMKMKNYNKPWEPKWTKICSLHSLPPQS
PTMs - P03928 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T31 | Phosphorylation | Uniprot | |
| Y33 | Phosphorylation | Uniprot | |
| S38 | Phosphorylation | Uniprot | |
| K40 | Ubiquitination | Uniprot | |
| Y47 | Phosphorylation | Uniprot | |
| K49 | Acetylation | Uniprot | |
| K54 | Ubiquitination | Uniprot | |
| K57 | Ubiquitination | Uniprot |
研究背景
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity).
Mitochondrion membrane>Single-pass membrane protein.
F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MD and ATP5MPL (By similarity).
Belongs to the ATPase protein 8 family.
研究領域
· Human Diseases > Neurodegenerative diseases > Alzheimer's disease.
· Human Diseases > Neurodegenerative diseases > Parkinson's disease.
· Human Diseases > Neurodegenerative diseases > Huntington's disease.
· Metabolism > Energy metabolism > Oxidative phosphorylation.
· Metabolism > Global and overview maps > Metabolic pathways.
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