ABCB8 Antibody - #DF9249
| 製品: | ABCB8 Antibody |
| カタログ: | DF9249 |
| タンパク質の説明: | Rabbit polyclonal antibody to ABCB8 |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat |
| 分子量: | 80 kDa; 80kD(Calculated). |
| ユニプロット: | Q9NUT2 |
| RRID: | AB_2842445 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF9249, RRID:AB_2842445.
折りたたみ／展開
;ATP binding cassette sub family B member 8; ABCB8; ABCB8_HUMAN; ATP binding cassette sub family B (MDR/TAP) member 8; ATP binding cassette sub family B member 8 mitochondrial; ATP-binding cassette sub-family B member 8; EST328128; M ABC1; M-ABC1; MABC1; Mitochondrial ABC protein; mitochondrial; Mitochondrial ATP binding cassette 1; Mitochondrial ATP-binding cassette 1;
免疫原
- Q9NUT2 MITOS_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLVHLFRVGIRGGPFPGRLLPPLRFQTFSAVRNTWRNGKTGQLHKAEGEYSDGYRSSSLLRAVAHLRSQLWAHLPRAPLAPRWSPSAWCWVGGALLGPMVLSKHPHLCLVALCEAEEAPPASSTPHVVGSRFNWKLFWQFLHPHLLVLGVAVVLALGAALVNVQIPLLLGQLVEVVAKYTRDHVGSFMTESQNLSTHLLILYGVQGLLTFGYLVLLSHVGERMAVDMRRALFSSLLRQDITFFDANKTGQLVSRLTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQRSMANLSVLFGQVVRGLSAGARVFEYMALNPCIPLSGGCCVPKEQLRGSVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGTTIMENIRFGKLEASDEEVYTAAREANAHEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESERVVQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGLYAELIRRQALDAPRTAAPPPKKPEGPRSHQHKS
PTMs - Q9NUT2 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S84 | Phosphorylation | Uniprot | |
| S86 | Phosphorylation | Uniprot | |
| S102 | Phosphorylation | Uniprot | |
| S233 | Phosphorylation | Uniprot | |
| K247 | Ubiquitination | Uniprot | |
| T257 | Phosphorylation | Uniprot | |
| K263 | Ubiquitination | Uniprot | |
| S271 | Phosphorylation | Uniprot | |
| S276 | Phosphorylation | Uniprot | |
| T295 | Phosphorylation | Uniprot | |
| T310 | Phosphorylation | Uniprot | |
| S314 | Phosphorylation | Uniprot | |
| S429 | Phosphorylation | Uniprot | |
| K465 | Ubiquitination | Uniprot | |
| K513 | Ubiquitination | Uniprot | |
| T540 | Phosphorylation | Uniprot | |
| S544 | Phosphorylation | Uniprot | |
| K573 | Ubiquitination | Uniprot | |
| S577 | Phosphorylation | Uniprot | |
| K617 | Ubiquitination | Uniprot | |
| K628 | Ubiquitination | Uniprot | |
| K699 | Ubiquitination | Uniprot |
研究背景
ATP-binding subunit of the mitochondrial potassium channel located in the mitochondrial inner membrane. Together with CCDC51/MITOK, forms a protein complex localized in the mitochondria that mediates ATP-dependent potassium currents across the inner membrane (that is, mitoK(ATP) channel). Plays a role in mitochondrial iron transport. Required for maintenance of normal cardiac function, possibly by influencing mitochondrial iron export and regulating the maturation of cytosolic iron sulfur cluster-containing enzymes (By similarity).
Mitochondrion inner membrane>Multi-pass membrane protein.
Ubiquitous.
The mitochondrial potassium channel (mitoK(ATP)) is composed of 4 subunits of CCDC51/MITOK and 4 subunits of ABCB8/MITOSUR (Probable). Interacts with C10orf88/PAAT. Interacts with NRP1; NRP1 regulates ABCB8/MITOSUR protein levels in mitochondria.
Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
研究領域
· Environmental Information Processing > Membrane transport > ABC transporters.
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