KCNJ8 Antibody - #DF9263
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| 製品: | KCNJ8 Antibody |
| カタログ: | DF9263 |
| タンパク質の説明: | Rabbit polyclonal antibody to KCNJ8 |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat, Rabbit |
| 予測: | Pig, Zebrafish, Bovine, Horse, Sheep, Dog, Chicken, Xenopus |
| 分子量: | 48 kDa; 48kD(Calculated). |
| ユニプロット: | Q15842 |
| RRID: | AB_2842459 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF9263, RRID:AB_2842459.
折りたたみ／展開
uKATP-1;KCNJ8; Kir6.1;uKATP 1;Potassium channel, inwardly rectifying subfamily J member 8;Inward rectifier K(+) channel Kir6.1;
免疫原
- Q15842 KCNJ8_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLARKSIIPEEYVLARIAAENLRKPRIRDRLPKARFIAKSGACNLAHKNIREQGRFLQDIFTTLVDLKWRHTLVIFTMSFLCSWLLFAIMWWLVAFAHGDIYAYMEKSGMEKSGLESTVCVTNVRSFTSAFLFSIEVQVTIGFGGRMMTEECPLAITVLILQNIVGLIINAVMLGCIFMKTAQAHRRAETLIFSRHAVIAVRNGKLCFMFRVGDLRKSMIISASVRIQVVKKTTTPEGEVVPIHQLDIPVDNPIESNNIFLVAPLIICHVIDKRSPLYDISATDLANQDLEVIVILEGVVETTGITTQARTSYIAEEIQWGHRFVSIVTEEEGVYSVDYSKFGNTVKVAAPRCSARELDEKPSILIQTLQKSELSHQNSLRKRNSMRRNNSMRRNNSIRRNNSSLMVPKVQFMTPEGNQNTSES
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q15842 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S6 | Phosphorylation | Uniprot | |
| T62 | Phosphorylation | Uniprot | |
| S194 | Phosphorylation | Uniprot | |
| K217 | Acetylation | Uniprot | |
| T234 | Phosphorylation | Uniprot | |
| S275 | Phosphorylation | Uniprot | |
| Y278 | Phosphorylation | Uniprot | |
| S281 | Phosphorylation | Uniprot | |
| T283 | Phosphorylation | Uniprot | |
| S385 | Phosphorylation | Uniprot | |
| S397 | Phosphorylation | Uniprot | |
| S403 | Phosphorylation | Uniprot |
研究背景
This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium (By similarity).
Membrane>Multi-pass membrane protein.
Predominantly detected in fetal and adult heart.
Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ8 subfamily.
研究領域
· Environmental Information Processing > Signal transduction > cGMP-PKG signaling pathway. (View pathway)
参考文献
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