製品: CAMLG Antibody
カタログ: DF9297
タンパク質の説明: Rabbit polyclonal antibody to CAMLG
アプリケーション: WB IHC
反応性: Human
予測: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
分子量: 33 kDa; 33kD(Calculated).
ユニプロット: P49069
RRID: AB_2842493

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製品説明

ソース:
Rabbit
アプリケーション:
IHC 1:50-1:200, WB 1:1000-3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human
予測:
Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(88%), Dog(100%), Chicken(88%), Xenopus(86%)
クローナリティ:
Polyclonal
特異性:
CAMLG Antibody detects endogenous levels of total CAMLG.
RRID:
AB_2842493
引用形式: Affinity Biosciences Cat# DF9297, RRID:AB_2842493.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ/展開

calcium modulating cyclophilin ligand; calcium modulating ligand; Calcium signal modulating cyclophilin ligand; CAML; cyclophilin B binding protein; MGC163197;

免疫原

免疫原:
Uniprot:
遺伝子(ID):
発現特異性:
P49069 CAMLG_HUMAN:

Ubiquitous. Highest levels in brain, testis and ovary.

タンパク質配列:
MESMAVATDGGERPGVPAGSGLSASQRRAELRRRKLLMNSEQRINRIMGFHRPGSGAEEESQTKSKQQDSDKLNSLSVPSVSKRVVLGDSVSTGTTDQQGGVAEVKGTQLGDKLDSFIKPPECSSDVNLELRQRNRGDLTADSVQRGSRHGLEQYLSRFEEAMKLRKQLISEKPSQEDGNTTEEFDSFRIFRLVGCALLALGVRAFVCKYLSIFAPFLTLQLAYMGLYKYFPKSEKKIKTTVLTAALLLSGIPAEVINRSMDTYSKMGEVFTDLCVYFFTFIFCHELLDYWGSEVP

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Chicken
88
Rabbit
88
Xenopus
86
Zebrafish
71
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - P49069 基板として

Site PTM Type Enzyme
T8 Phosphorylation
S23 Phosphorylation
S25 Phosphorylation
S40 Phosphorylation
S55 Phosphorylation
S61 Phosphorylation
K72 Acetylation
K83 Acetylation
S116 Phosphorylation
S143 Phosphorylation
R146 Methylation
S148 Phosphorylation
Y155 Phosphorylation
K164 Ubiquitination
K173 Ubiquitination
S175 Phosphorylation
S250 Phosphorylation

研究背景

機能:

Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B.

細胞の位置付け:

Membrane>Multi-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Ubiquitous. Highest levels in brain, testis and ovary.

サブユニット構造:

The N-terminal domain binds to TNFRSF13B/TACI.

(Microbial infection) Interacts with human herpes virus 8/HHV-8 protein K7; this interaction modulates intracellular calcium concentration.

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