KCNMB3 Antibody - #DF9302
| 製品: | KCNMB3 Antibody |
| カタログ: | DF9302 |
| タンパク質の説明: | Rabbit polyclonal antibody to KCNMB3 |
| アプリケーション: | WB |
| 反応性: | Human |
| 分子量: | 32 kDa; 32kD(Calculated). |
| ユニプロット: | Q9NPA1 |
| RRID: | AB_2842498 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF9302, RRID:AB_2842498.
折りたたみ／展開
BK channel subunit beta 3; BK channel subunit beta-3; BKbeta 3; BKbeta3; Calcium activated potassium channel beta 3 subunit; Calcium activated potassium channel subfamily M subunit beta 3; Calcium activated potassium channel subunit beta 3; Calcium-activated potassium channel; Calcium-activated potassium channel subunit beta-3; Charybdotoxin receptor subunit beta 3; Charybdotoxin receptor subunit beta-3; EG435726; Gm5707; Hbeta 3; Hbeta3; K(VCA)beta 3; K(VCA)beta-3; KCMB3_HUMAN; KCNMB 2; KCNMB 3; KCNMB2; KCNMB3; KCNMBL; Large conductance voltage and Ca2+ activated potassium channel Maxi K beta 3 subunit; Maxi K channel subunit beta 3; Maxi K channel subunit beta-3; Potassium channel, calcium-activated large conductance, subfamily M, beta member 3; Potassium large conductance calcium activated channel beta 3 subunit; Potassium large conductance calcium activated channel subfamily M beta member 3; Slo beta 3; Slo-beta-3; subfamily M subunit beta-3;
免疫原
Isoform 1, isoform 3 and isoform 4 are widely expressed. Isoform 2 is expressed placenta, pancreas, kidney and heart. Isoform 1 and isoform 3 are highly expressed in pancreas and testis.
- Q9NPA1 KCMB3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDFSPSSELGFHFVAFILLTRHRTAFPASGKKRETDYSDGDPLDVHKRLPSSAGEDRAVMLGFAMMGFSVLMFFLLGTTILKPFMLSIQREESTCTAIHTDIMDDWLDCAFTCGVHCHGQGKYPCLQVFVNLSHPGQKALLHYNEEAVQINPKCFYTPKCHQDRNDLLNSALDIKEFFDHKNGTPFSCFYSPASQSEDVILIKKYDQMAIFHCLFWPSLTLLGGALIVGMVRLTQHLSLLCEKYSTVVRDEVGGKVPYIEQHQFKLCIMRRSKGRAEKS
研究背景
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer.
N-glycosylated.
The extracellular domain contains disulfide bond essential for the gating mechanism.
Membrane>Multi-pass membrane protein.
Isoform 1, isoform 3 and isoform 4 are widely expressed. Isoform 2 is expressed placenta, pancreas, kidney and heart. Isoform 1 and isoform 3 are highly expressed in pancreas and testis.
Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB3 per KCNMA1 tetramer.
Isoform 4 cytoplasmic N-terminal domain participates in the partial inactivation of KCNMA1, possibly by binding to a receptor site.
The extracellular domain forms gates to block ion permeation, providing a mechanism by which current can be rapidly diminished upon cellular repolarization.
Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB3 subfamily.
研究領域
· Environmental Information Processing > Signal transduction > cGMP-PKG signaling pathway. (View pathway)
· Organismal Systems > Circulatory system > Vascular smooth muscle contraction. (View pathway)
· Organismal Systems > Endocrine system > Insulin secretion. (View pathway)
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