CHST12 Antibody - #DF9328
| 製品: | CHST12 Antibody |
| カタログ: | DF9328 |
| タンパク質の説明: | Rabbit polyclonal antibody to CHST12 |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 48 kDa; 48kD(Calculated). |
| ユニプロット: | Q9NRB3 |
| RRID: | AB_2842524 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF9328, RRID:AB_2842524.
折りたたみ／展開
C4S 2; C4S2; C4ST 2; C4ST2; Carbohydrate (chondroitin 4) sulfotransferase 12; Chondroitin 4 O sulfotransferase 2; Chondroitin 4 sulfotransferase 2; Sulfotransferase Hlo;
免疫原
Widely expressed. Expressed a high level in spinal chord, heart, spleen, thyroid, pituitary gland, adrenal gland, peripheral blood leukocytes, thymus, lung, small intestine, fetal kidney, fetal spleen and fetal lung.
- Q9NRB3 CHSTC_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTKARLFRLWLVLGSVFMILLIIVYWDSAGAAHFYLHTSFSRPHTGPPLPTPGPDRDRELTADSDVDEFLDKFLSAGVKQSDLPRKETEQPPAPGSMEESVRGYDWSPRDARRSPDQGRQQAERRSVLRGFCANSSLAFPTKERAFDDIPNSELSHLIVDDRHGAIYCYVPKVACTNWKRVMIVLSGSLLHRGAPYRDPLRIPREHVHNASAHLTFNKFWRRYGKLSRHLMKVKLKKYTKFLFVRDPFVRLISAFRSKFELENEEFYRKFAVPMLRLYANHTSLPASAREAFRAGLKVSFANFIQYLLDPHTEKLAPFNEHWRQVYRLCHPCQIDYDFVGKLETLDEDAAQLLQLLQVDRQLRFPPSYRNRTASSWEEDWFAKIPLAWRQQLYKLYEADFVLFGYPKPENLLRD
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9NRB3 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K72 | Ubiquitination | Uniprot | |
| S75 | Phosphorylation | Uniprot | |
| K79 | Ubiquitination | Uniprot | |
| K86 | Ubiquitination | Uniprot | |
| T88 | O-Glycosylation | Uniprot | |
| K142 | Ubiquitination | Uniprot | |
| K172 | Ubiquitination | Uniprot | |
| K240 | Ubiquitination | Uniprot | |
| K258 | Ubiquitination | Uniprot | |
| Y396 | Phosphorylation | Uniprot | |
| Y405 | Phosphorylation | Uniprot |
研究背景
Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Activity toward partially desulfated dermatan sulfate is however lower. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor.
Golgi apparatus membrane>Single-pass type II membrane protein.
Widely expressed. Expressed a high level in spinal chord, heart, spleen, thyroid, pituitary gland, adrenal gland, peripheral blood leukocytes, thymus, lung, small intestine, fetal kidney, fetal spleen and fetal lung.
Belongs to the sulfotransferase 2 family.
研究領域
· Metabolism > Glycan biosynthesis and metabolism > Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate.
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