CTNNA2 Antibody - #DF9347
| 製品: | CTNNA2 Antibody |
| カタログ: | DF9347 |
| タンパク質の説明: | Rabbit polyclonal antibody to CTNNA2 |
| アプリケーション: | WB |
| 反応性: | Human, Mouse |
| 予測: | Zebrafish, Bovine, Chicken, Xenopus |
| 分子量: | 105kDa; 105kD(Calculated). |
| ユニプロット: | P26232 |
| RRID: | AB_2842543 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF9347, RRID:AB_2842543.
折りたたみ／展開
Alpha catenin related protein; Alpha N catenin; Alpha N-catenin; Alpha-catenin-related protein; Cadherin associated protein related; Cancer/testis antigen 114; CAP R; CAPR; Catenin (cadherin associated protein) alpha 2; Catenin alpha 2; Catenin alpha-2; CT114; CTNA2_HUMAN; CTNN A2; CTNNA 2; CTNNA2; CTNR; DKFZp686H02198;
免疫原
Expressed in neural tissues, with strongest expression in fetal and adult brain. Expressed in the developing cortical plate and marginal zone of 20-week-old human fetal brain.
- P26232 CTNA2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTSATSPIILKWDPKSLEIRTLTVERLLEPLVTQVTTLVNTSNKGPSGKKKGRSKKAHVLAASVEQATQNFLEKGEQIAKESQDLKEELVAAVEDVRKQGETMRIASSEFADDPCSSVKRGTMVRAARALLSAVTRLLILADMADVMRLLSHLKIVEEALEAVKNATNEQDLANRFKEFGKEMVKLNYVAARRQQELKDPHCRDEMAAARGALKKNATMLYTASQAFLRHPDVAATRANRDYVFKQVQEAIAGISNAAQATSPTDEAKGHTGIGELAAALNEFDNKIILDPMTFSEARFRPSLEERLESIISGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYMNNTGRKEKGDPLNIAIDKMTKKTRDLRRQLRKAVMDHISDSFLETNVPLLVLIEAAKSGNEKEVKEYAQVFREHANKLVEVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTLAARPQSKVAQDNMDVFKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEMENYEAGVYTEKVLEATKLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDVRSRTSVQTEDDQLIAGQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVINAAKKIAEAGSRMDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGTGVQSTFTTFYEVDCDVIDGGRASQLSTHLPTCAEGAPIGSGSSDSSMLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQKVYGTAAVNSPVVSWKMKAPEKKPLVKREKPEEFQTRVRRGSQKKHISPVQALSEFKAMDSF
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P26232 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K15 | Ubiquitination | Uniprot | |
| T41 | Phosphorylation | Uniprot | |
| S42 | Phosphorylation | Uniprot | |
| S151 | Phosphorylation | Uniprot | |
| S302 | Phosphorylation | Uniprot | |
| S309 | Phosphorylation | Uniprot | |
| S321 | Phosphorylation | Uniprot | |
| K415 | Ubiquitination | Uniprot | |
| Y417 | Phosphorylation | Uniprot | |
| T535 | Phosphorylation | Uniprot | |
| R621 | Methylation | Uniprot | |
| S640 | Phosphorylation | Uniprot | |
| S651 | Phosphorylation | Uniprot | |
| T653 | Phosphorylation | Uniprot | |
| S654 | Phosphorylation | Uniprot | |
| T657 | Phosphorylation | Uniprot | |
| S667 | Phosphorylation | Uniprot | |
| K696 | Ubiquitination | Uniprot | |
| T738 | Phosphorylation | Uniprot | |
| S739 | Phosphorylation | Uniprot | |
| S753 | Phosphorylation | Uniprot | |
| Y778 | Phosphorylation | Uniprot | |
| K889 | Acetylation | Uniprot | |
| K889 | Ubiquitination | Uniprot | |
| S939 | Phosphorylation | Uniprot | |
| S945 | Phosphorylation | Uniprot |
研究背景
May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system (By similarity). Required for proper regulation of cortical neuronal migration and neurite growth. It acts as negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization. It thereby suppresses excessive actin branching which would impair neurite growth and stability. Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (By similarity).
Cell membrane>Peripheral membrane protein>Cytoplasmic side. Cytoplasm. Cytoplasm>Cytoskeleton. Cell junction>Adherens junction. Cell projection>Axon. Nucleus.
Expressed in neural tissues, with strongest expression in fetal and adult brain. Expressed in the developing cortical plate and marginal zone of 20-week-old human fetal brain.
Interacts with CDH1 and CDH2 (By similarity). Interacts with ZNF639; recruits CTNNA2 to the nucleus. Interacts with F-actin.
Belongs to the vinculin/alpha-catenin family.
研究領域
· Cellular Processes > Cellular community - eukaryotes > Adherens junction. (View pathway)
· Environmental Information Processing > Signal transduction > Hippo signaling pathway. (View pathway)
· Human Diseases > Infectious diseases: Bacterial > Bacterial invasion of epithelial cells.
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Human Diseases > Cancers: Specific types > Endometrial cancer. (View pathway)
· Human Diseases > Cancers: Specific types > Gastric cancer. (View pathway)
· Human Diseases > Cardiovascular diseases > Arrhythmogenic right ventricular cardiomyopathy (ARVC).
· Organismal Systems > Immune system > Leukocyte transendothelial migration. (View pathway)
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