PDE3B Antibody - #DF9372
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF9372, RRID:AB_2842568.
折りたたみ／展開
5''-cyclic phosphodiesterase B; Adipocyte cAMP phosphodiesterase cGMP inhibited; AI847709; cAMP Phosphodiesterase, adipocyte, cGMP-inhibited; CGI-PDE B; CGIP1; CGIPDE B; CGIPDE1; cGMP inhibited 3 5 cyclic phosphodiesterase B; CGMP inhibited cAMP phophodiesterase; cGMP-inhibited 3''; Cyclic GMP inhibited phosphodiesterase B; Cyclic GMP-inhibited phosphodiesterase B; Cyclic nucleotide phosphodiesterase; HcGIP1; HcGIP1, rat, homolog of; Pde3b; PDE3B_HUMAN; Phosphodiesterase 3B; Phosphodiesterase 3B cGMP inhibited;
免疫原
- Q13370 PDE3B_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MRRDERDAKAMRSLQPPDGAGSPPESLRNGYVKSCVSPLRQDPPRGFFFHLCRFCNVELRPPPASPQQPRRCSPFCRARLSLGALAAFVLALLLGAEPESWAAGAAWLRTLLSVCSHSLSPLFSIACAFFFLTCFLTRTKRGPGPGRSCGSWWLLALPACCYLGDFLVWQWWSWPWGDGDAGSAAPHTPPEAAAGRLLLVLSCVGLLLTLAHPLRLRHCVLVLLLASFVWWVSFTSLGSLPSALRPLLSGLVGGAGCLLALGLDHFFQIREAPLHPRLSSAAEEKVPVIRPRRRSSCVSLGETAASYYGSCKIFRRPSLPCISREQMILWDWDLKQWYKPHYQNSGGGNGVDLSVLNEARNMVSDLLTDPSLPPQVISSLRSISSLMGAFSGSCRPKINPLTPFPGFYPCSEIEDPAEKGDRKLNKGLNRNSLPTPQLRRSSGTSGLLPVEQSSRWDRNNGKRPHQEFGISSQGCYLNGPFNSNLLTIPKQRSSSVSLTHHVGLRRAGVLSSLSPVNSSNHGPVSTGSLTNRSPIEFPDTADFLNKPSVILQRSLGNAPNTPDFYQQLRNSDSNLCNSCGHQMLKYVSTSESDGTDCCSGKSGEEENIFSKESFKLMETQQEEETEKKDSRKLFQEGDKWLTEEAQSEQQTNIEQEVSLDLILVEEYDSLIEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQFMNYFRALENGYRDIPYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRINHGRIAYISSKSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNAKANDVNSNGIEWSNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEEANLGLPISPFMDRSSPQLAKLQESFITHIVGPLCNSYDAAGLLPGQWLEAEEDNDTESGDDEDGEELDTEDEEMENNLNPKPPRRKSRRRIFCQLMHHLTENHKIWKEIVEEEEKCKADGNKLQVENSSLPQADEIQVIEEADEEE
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q13370 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S22 | Phosphorylation | Uniprot | |
| S26 | Phosphorylation | Uniprot | |
| K33 | Ubiquitination | Uniprot | |
| S37 | Phosphorylation | Uniprot | |
| S65 | Phosphorylation | Uniprot | |
| S73 | Phosphorylation | P17612 (PRKACA) | Uniprot |
| S279 | Phosphorylation | Uniprot | |
| S280 | Phosphorylation | Uniprot | |
| K285 | Ubiquitination | Uniprot | |
| S295 | Phosphorylation | P31749 (AKT1) | Uniprot |
| S296 | Phosphorylation | P17612 (PRKACA) | Uniprot |
| S299 | Phosphorylation | Uniprot | |
| T303 | Phosphorylation | Uniprot | |
| S306 | Phosphorylation | Uniprot | |
| S310 | Phosphorylation | Uniprot | |
| K312 | Ubiquitination | Uniprot | |
| S318 | Phosphorylation | P17612 (PRKACA) | Uniprot |
| S323 | Phosphorylation | Uniprot | |
| K339 | Ubiquitination | Uniprot | |
| S371 | Phosphorylation | Uniprot | |
| S378 | Phosphorylation | Uniprot | |
| S379 | Phosphorylation | Uniprot | |
| S393 | Phosphorylation | Uniprot | |
| K419 | Ubiquitination | Uniprot | |
| K426 | Ubiquitination | Uniprot | |
| S432 | Phosphorylation | Uniprot | |
| T435 | Phosphorylation | Uniprot | |
| S442 | Phosphorylation | Uniprot | |
| T444 | Phosphorylation | Uniprot | |
| S445 | Phosphorylation | Uniprot | |
| T487 | Phosphorylation | Uniprot | |
| S495 | Phosphorylation | Uniprot | |
| S514 | Phosphorylation | Uniprot | |
| S518 | Phosphorylation | Uniprot | |
| K546 | Ubiquitination | Uniprot | |
| S554 | Phosphorylation | Uniprot | |
| T561 | Phosphorylation | Uniprot | |
| Y565 | Phosphorylation | Uniprot | |
| S571 | Phosphorylation | Uniprot | |
| S573 | Phosphorylation | Uniprot | |
| S578 | Phosphorylation | Uniprot | |
| K585 | Ubiquitination | Uniprot | |
| Y586 | Phosphorylation | Uniprot | |
| S588 | Phosphorylation | Uniprot | |
| K601 | Ubiquitination | Uniprot | |
| S602 | Phosphorylation | Uniprot | |
| K611 | Ubiquitination | Uniprot | |
| S613 | Phosphorylation | Uniprot | |
| K632 | Ubiquitination | Uniprot | |
| Y751 | Phosphorylation | Uniprot | |
| T769 | Phosphorylation | Uniprot | |
| T773 | Phosphorylation | Uniprot | |
| K943 | Ubiquitination | Uniprot | |
| S981 | Phosphorylation | Uniprot | |
| K1073 | Ubiquitination | Uniprot | |
| K1081 | Ubiquitination | Uniprot |
研究背景
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.
Membrane>Multi-pass membrane protein.
Abundant in adipose tissues.
Interacts with PIK3CG (By similarity). Interacts with RAPGEF3 and PIK3R6.
Belongs to the cyclic nucleotide phosphodiesterase family. PDE3 subfamily.
研究領域
· Environmental Information Processing > Signal transduction > cGMP-PKG signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > cAMP signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Apelin signaling pathway. (View pathway)
· Human Diseases > Substance dependence > Morphine addiction.
· Metabolism > Nucleotide metabolism > Purine metabolism.
· Organismal Systems > Endocrine system > Insulin signaling pathway. (View pathway)
· Organismal Systems > Endocrine system > Progesterone-mediated oocyte maturation.
· Organismal Systems > Endocrine system > Glucagon signaling pathway.
· Organismal Systems > Endocrine system > Regulation of lipolysis in adipocytes.
· Organismal Systems > Endocrine system > Renin secretion.
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