製品: Claudin 14 Antibody
カタログ: DF9391
タンパク質の説明: Rabbit polyclonal antibody to Claudin 14
アプリケーション: WB IHC
反応性: Human, Mouse, Rat
予測: Pig, Bovine, Horse, Rabbit, Dog, Chicken
分子量: 26 kDa; 26kD(Calculated).
ユニプロット: O95500
RRID: AB_2842587

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製品説明

ソース:
Rabbit
アプリケーション:
WB 1:1000-3000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
予測:
Pig(80%), Bovine(90%), Horse(90%), Rabbit(100%), Dog(80%), Chicken(90%)
クローナリティ:
Polyclonal
特異性:
Claudin 14 Antibody detects endogenous levels of total Claudin 14.
RRID:
AB_2842587
引用形式: Affinity Biosciences Cat# DF9391, RRID:AB_2842587.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ/展開

AI851731; Claudin 14; Claudin-14; CLD14_HUMAN; CLDN 14; CLDN14; DFNB 29; DFNB29; Human CLDN14 gene; MGC109472; OTTHUMP00000109046; OTTHUMP00000109049; OTTMUSP00000021531; UNQ777/PRO1571;

免疫原

免疫原:
Uniprot:
遺伝子(ID):
発現特異性:
O95500 CLD14_HUMAN:

Liver, kidney. Also found in ear.

タンパク質配列:
MASTAVQLLGFLLSFLGMVGTLITTILPHWRRTAHVGTNILTAVSYLKGLWMECVWHSTGIYQCQIYRSLLALPQDLQAARALMVISCLLSGIACACAVIGMKCTRCAKGTPAKTTFAILGGTLFILAGLLCMVAVSWTTNDVVQNFYNPLLPSGMKFEIGQALYLGFISSSLSLIGGTLLCLSCQDEAPYRPYQAPPRATTTTANTAPAYQPPAAYKDNRAPSVTSATHSGYRLNDYV

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Rabbit
100
Horse
90
Bovine
90
Chicken
90
Pig
80
Dog
80
Xenopus
70
Sheep
0
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - O95500 基板として

Site PTM Type Enzyme
Y194 Phosphorylation
Y211 Phosphorylation
Y217 Phosphorylation
Y233 Phosphorylation

研究背景

機能:

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

細胞の位置付け:

Cell junction>Tight junction. Cell membrane>Multi-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Liver, kidney. Also found in ear.

タンパク質ファミリー:

Belongs to the claudin family.

研究領域

· Cellular Processes > Cellular community - eukaryotes > Tight junction.   (View pathway)

· Environmental Information Processing > Signaling molecules and interaction > Cell adhesion molecules (CAMs).   (View pathway)

· Human Diseases > Infectious diseases: Viral > Hepatitis C.

· Organismal Systems > Immune system > Leukocyte transendothelial migration.   (View pathway)

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