CLDN18 Antibody - #DF9392
| 製品: | CLDN18 Antibody |
| カタログ: | DF9392 |
| タンパク質の説明: | Rabbit polyclonal antibody to CLDN18 |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat, Monkey |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit |
| 分子量: | 28 kDa; 28kD(Calculated). |
| ユニプロット: | P56856 |
| RRID: | AB_2842588 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF9392, RRID:AB_2842588.
折りたたみ／展開
Claudin 18; Claudin-18; CLD18_HUMAN; CLDN18; SFTA5; SFTPJ;
免疫原
Isoform A1: Expression is restricted to the lung (PubMed:19047087). Isoform A2: Expression is restricted to the stomach mucosa where it is predominantly observed in the epithelial cells of the pit region and the base of the gastric glands including exocrine and endocrine cells (at protein level) (PubMed:19047087).
- P56856 CLD18_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSTTTCQVVAFLLSILGLAGCIAATGMDMWSTQDLYDNPVTSVFQYEGLWRSCVRQSSGFTECRPYFTILGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLTSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWVAGGLTLIGGVMMCIACRGLAPEETNYKAVSYHASGHSVAYKPGGFKASTGFGSNTKNKKIYDGGARTEDEVQSYPSKHDYV
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P56856 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y206 | Phosphorylation | Uniprot | |
| S210 | Phosphorylation | Uniprot | |
| Y211 | Phosphorylation | Uniprot | |
| S214 | Phosphorylation | Uniprot | |
| S217 | Phosphorylation | Uniprot | |
| Y220 | Phosphorylation | Uniprot | |
| T229 | Phosphorylation | Uniprot | |
| Y241 | Phosphorylation | Uniprot | |
| T247 | Phosphorylation | Uniprot | |
| S253 | Phosphorylation | Uniprot | |
| Y254 | Phosphorylation | Uniprot | |
| S256 | Phosphorylation | Uniprot | |
| Y260 | Phosphorylation | Uniprot |
研究背景
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Cell junction>Tight junction. Cell membrane>Multi-pass membrane protein.
Note: Localizes to tight junctions in epithelial cells.
Isoform A1: Expression is restricted to the lung. Isoform A2: Expression is restricted to the stomach mucosa where it is predominantly observed in the epithelial cells of the pit region and the base of the gastric glands including exocrine and endocrine cells (at protein level).
Belongs to the claudin family.
研究領域
· Cellular Processes > Cellular community - eukaryotes > Tight junction. (View pathway)
· Environmental Information Processing > Signaling molecules and interaction > Cell adhesion molecules (CAMs). (View pathway)
· Human Diseases > Infectious diseases: Viral > Hepatitis C.
· Organismal Systems > Immune system > Leukocyte transendothelial migration. (View pathway)
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