CNGA3 Antibody - #DF9419
| 製品: | CNGA3 Antibody |
| カタログ: | DF9419 |
| タンパク質の説明: | Rabbit polyclonal antibody to CNGA3 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human |
| 分子量: | 79 kDa; 79kD(Calculated). |
| ユニプロット: | Q16281 |
| RRID: | AB_2842615 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF9419, RRID:AB_2842615.
折りたたみ／展開
ACHM2; CCNC1; CCNCa; CCNCalpha; CNCG3; CNG 3; CNG channel alpha 3; CNG channel alpha-3; CNG-3; CNG3; CNGA3; Cnga3 cyclic nucleotide gated channel alpha 3; CNGA3_HUMAN; Cone photoreceptor cGMP gated channel; Cone photoreceptor cGMP gated channel alpha subunit; Cone photoreceptor cGMP gated channel subunit alpha; Cone photoreceptor cGMP-gated channel subunit alpha; Cyclic nucleotide gated cation channel alpha 3; Cyclic nucleotide gated channel alpha 3; Cyclic nucleotide gated channel olfactory 3; Cyclic nucleotide gated channel rod photoreceptor subunit alpha; Cyclic nucleotide-gated cation channel alpha-3; Cyclic nucleotide-gated channel alpha-3; OTTHUMP00000161120;
免疫原
- Q16281 CNGA3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAKINTQYSHPSRTHLKVKTSDRDLNRAENGLSRAHSSSEETSSVLQPGIAMETRGLADSGQGSFTGQGIARLSRLIFLLRRWAARHVHHQDQGPDSFPDRFRGAELKEVSSQESNAQANVGSQEPADRGRSAWPLAKCNTNTSNNTEEEKKTKKKDAIVVDPSSNLYYRWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYSADVLYVLDVLVRARTGFLEQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYLKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLYWSTLTLTTIGETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKALEEKGRQILMKDNLIDEELARAGADPKDLEEKVEQLGSSLDTLQTRFARLLAEYNATQMKMKQRLSQLESQVKGGGDKPLADGEVPGDATKTEDKQQ
PTMs - Q16281 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K138 | Acetylation | Uniprot | |
| K154 | Acetylation | Uniprot | |
| K155 | Acetylation | Uniprot | |
| Y168 | Phosphorylation | Uniprot | |
| Y169 | Phosphorylation | Uniprot | |
| S282 | Phosphorylation | Uniprot |
研究背景
Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones.
Membrane>Multi-pass membrane protein.
Prominently expressed in retina.
Tetramer formed of three CNGA3 and one CNGB3 modulatory subunits.
The C-terminal coiled-coil domain mediates homotrimerization of CNGA subunits.
Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA3 subfamily.
研究領域
· Environmental Information Processing > Signal transduction > cAMP signaling pathway. (View pathway)
· Organismal Systems > Sensory system > Olfactory transduction.
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