ASAP2 Antibody - #DF9441
| 製品: | ASAP2 Antibody |
| カタログ: | DF9441 |
| タンパク質の説明: | Rabbit polyclonal antibody to ASAP2 |
| アプリケーション: | WB |
| 反応性: | Human, Mouse |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 112 kDa; 112kD(Calculated). |
| ユニプロット: | O43150 |
| RRID: | AB_2842637 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF9441, RRID:AB_2842637.
折りたたみ／展開
AMAP 2; AMAP2; ANK repeat and PH domain-containing protein 2; Arf-GAP with SH3 domain; ArfGAP with SH3 domain, ankyrin repeat and PH domain 2; ASAP2; ASAP2_HUMAN; centaurin, beta 3; CENTB3; DDEF 2; DDEF2; Development and differentiation enhancing factor 2; Development and differentiation-enhancing factor 2; FLJ42910; KIAA0400; PAG 3; PAG3; Pap alpha; PAP; Paxillin associated protein with ARFGAP activity 3; Paxillin-associated protein with ARF GAP activity 3; Pyk2 C terminus associated protein; Pyk2 C-terminus-associated protein; SHAG 1; SHAG1;
免疫原
- O43150 ASAP2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPDQISVSEFVAETHEDYKAPTASSFTTRTAQCRNTVAAIEEALDVDRMVLYKMKKSVKAINSSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKFSVFTKELTALFKNLIQNMNNIISFPLDSLLKGDLKGVKGDLKKPFDKAWKDYETKITKIEKEKKEHAKLHGMIRTEISGAEIAEEMEKERRFFQLQMCEYLLKVNEIKIKKGVDLLQNLIKYFHAQCNFFQDGLKAVESLKPSIETLSTDLHTIKQAQDEERRQLIQLRDILKSALQVEQKEDSQIRQSTAYSLHQPQGNKEHGTERNGSLYKKSDGIRKVWQKRKCSVKNGFLTISHGTANRPPAKLNLLTCQVKTNPEEKKCFDLISHDRTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENNIVQELTKEIISEVQRMTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDVLGTSELLLAKNIGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYARKKHADNAAKLHSLCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRSVDRTSLHIVDFLVQNSGNLDKQTGKGSTALHYCCLTDNAECLKLLLRGKASIEIANESGETPLDIAKRLKHEHCEELLTQALSGRFNSHVHVEYEWRLLHEDLDESDDDMDEKLQPSPNRREDRPISFYQLGSNQLQSNAVSLARDAANLAKEKQRAFMPSILQNETYGALLSGSPPPAQPAAPSTTSAPPLPPRNVGKVQTASSANTLWKTNSVSVDGGSRQRSSSDPPAVHPPLPPLRVTSTNPLTPTPPPPVAKTPSVMEALSQPSKPAPPGISQIRPPPLPPQPPSRLPQKKPAPGADKSTPLTNKGQPRGPVDLSATEALGPLSNAMVLQPPAPMPRKSQATKLKPKRVKALYNCVADNPDELTFSEGDVIIVDGEEDQEWWIGHIDGDPGRKGAFPVSFVHFIAD
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O43150 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K81 | Ubiquitination | Uniprot | |
| Y201 | Phosphorylation | Uniprot | |
| K212 | Ubiquitination | Uniprot | |
| K242 | Acetylation | Uniprot | |
| K242 | Ubiquitination | Uniprot | |
| K274 | Ubiquitination | Uniprot | |
| K282 | Ubiquitination | Uniprot | |
| S285 | Phosphorylation | Uniprot | |
| Y293 | Phosphorylation | Uniprot | |
| S294 | Phosphorylation | Uniprot | |
| S311 | Phosphorylation | Uniprot | |
| K321 | Acetylation | Uniprot | |
| K325 | Acetylation | Uniprot | |
| S329 | Phosphorylation | Uniprot | |
| T336 | Phosphorylation | Uniprot | |
| S338 | Phosphorylation | Uniprot | |
| K405 | Ubiquitination | Uniprot | |
| K546 | Ubiquitination | Uniprot | |
| K555 | Ubiquitination | Uniprot | |
| T556 | Phosphorylation | Uniprot | |
| K662 | Ubiquitination | Uniprot | |
| Y689 | Phosphorylation | Uniprot | |
| S701 | Phosphorylation | Uniprot | |
| S712 | Phosphorylation | Uniprot | |
| S722 | Phosphorylation | Uniprot | |
| Y724 | Phosphorylation | Uniprot | |
| S728 | Phosphorylation | Uniprot | |
| Y763 | Phosphorylation | Uniprot | |
| S800 | Phosphorylation | Uniprot | |
| S809 | Phosphorylation | Uniprot | |
| S820 | Phosphorylation | Uniprot | |
| S822 | Phosphorylation | Uniprot | |
| T845 | Phosphorylation | Uniprot | |
| T900 | Phosphorylation | Uniprot | |
| T903 | Phosphorylation | Uniprot |
研究背景
Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration.
Phosphorylated on tyrosine residues by SRC and PTK2B.
Cytoplasm. Golgi apparatus>Golgi stack membrane>Peripheral membrane protein. Cell membrane>Peripheral membrane protein.
Note: Colocalizes with F-actin and ARF6 in phagocytic cups.
Detected in heart, brain, placenta, kidney, monocytes and pancreas.
Binds PXN, ARF1, ARF5, ARF6, PTK2B and SRC.
The conserved Arg-464 in the Arf-GAP domain probably becomes part of the active site of bound small GTPases and is necessary for GTP hydrolysis.
研究領域
· Cellular Processes > Transport and catabolism > Endocytosis. (View pathway)
· Organismal Systems > Immune system > Fc gamma R-mediated phagocytosis. (View pathway)
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